TY - JOUR
T1 - Attenuated psychotic and basic symptom characteristics in adolescents with ultra-high risk criteria for psychosis, other non-psychotic psychiatric disorders and early-onset psychosis
AU - Lo Cascio, Nella
AU - Saba, Riccardo
AU - Hauser, Marta
AU - Vernal, Ditte Lammers
AU - Al-Jadiri, Aseel
AU - Borenstein, Yehonatan
AU - Sheridan, Eva M.
AU - Kishimoto, Taishiro
AU - Armando, Marco
AU - Vicari, Stefano
AU - Fiori Nastro, Paolo
AU - Girardi, Paolo
AU - Gebhardt, Eva
AU - Kane, John M.
AU - Auther, Andrea
AU - Carrión, Ricardo E.
AU - Cornblatt, Barbara A.
AU - Schimmelmann, Benno G.
AU - Schultze-Lutter, Frauke
AU - Correll, Christoph U.
N1 - Funding Information:
The paper is based on the resident thesis of Dr. Lo Cascio, which was supervised by Drs. Girardi, Fiori Nastro and Correll. This work was partially supported by the NIMH Advanced Center for Services and Intervention Research, The Zucker Hillside Hospital (P30MH090590). Dr. Marco Armando is supported by a Brain and Behavior Research Foundation (formerly NARSAD) Young Investigator Award. Ms Lammers Vernal’s research rotation at the Zucker Hillside Hospital was supported by the Research Unit for Child and Adolescent Psychiatry, Psychiatric Hospital and the Psychiatric Research Fund, North Denmark Region as well as by Aarhus University.
Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - While attenuated psychotic symptoms (APS) and basic symptoms (BS) are the main current predictors of psychosis in adults, studies in adolescents are scarce. Thus, we (1) described the prevalence and severity of positive, negative, disorganization, general, and basic symptoms in adolescent patients at ultra-high risk for psychosis (UHR), with other non-psychotic psychiatric disorders (PC) and with early-onset psychosis (EOP); and (2) investigated BS criteria in relation to UHR criteria. Sixty-nine 12–18-year-old adolescents (15.3 ± 1.7 years, female = 58.0 %, UHR = 22, PC = 27, EOP = 20) were assessed with the structured interview for prodromal syndromes (SIPS) and the schizophrenia proneness instrument-child and youth version (SPI-CY). Despite similar current and past 12-month global functioning, both UHR and EOP had significantly higher SIPS total and subscale scores compared to PC, with moderate-large effect sizes. Expectedly, UHR had significantly lower SIPS positive symptom scores than EOP, but similar SIPS negative, disorganized, and general symptom scores. Compared to PC, both EOP and UHR had more severe basic thought and perception disturbances, and significantly more often met cognitive disturbances criteria (EOP = 50.0 %, UHR = 40.9 %, PC = 14.8 %). Compared to UHR, both EOP and PC significantly less often met cognitive-perceptive BS criteria (EOP = 35.0 %, UHR = 68.2 %, PC = 25.9 %). BS were significantly more prevalent in both EOP and UHR than PC, and UHR were similar to EOP in symptom domains. Given the uncertain outcome of adolescents at clinical high-risk of psychosis, future research is needed to determine whether the combined assessment of early subjective disturbances with observable APS can improve the accuracy of psychosis prediction.
AB - While attenuated psychotic symptoms (APS) and basic symptoms (BS) are the main current predictors of psychosis in adults, studies in adolescents are scarce. Thus, we (1) described the prevalence and severity of positive, negative, disorganization, general, and basic symptoms in adolescent patients at ultra-high risk for psychosis (UHR), with other non-psychotic psychiatric disorders (PC) and with early-onset psychosis (EOP); and (2) investigated BS criteria in relation to UHR criteria. Sixty-nine 12–18-year-old adolescents (15.3 ± 1.7 years, female = 58.0 %, UHR = 22, PC = 27, EOP = 20) were assessed with the structured interview for prodromal syndromes (SIPS) and the schizophrenia proneness instrument-child and youth version (SPI-CY). Despite similar current and past 12-month global functioning, both UHR and EOP had significantly higher SIPS total and subscale scores compared to PC, with moderate-large effect sizes. Expectedly, UHR had significantly lower SIPS positive symptom scores than EOP, but similar SIPS negative, disorganized, and general symptom scores. Compared to PC, both EOP and UHR had more severe basic thought and perception disturbances, and significantly more often met cognitive disturbances criteria (EOP = 50.0 %, UHR = 40.9 %, PC = 14.8 %). Compared to UHR, both EOP and PC significantly less often met cognitive-perceptive BS criteria (EOP = 35.0 %, UHR = 68.2 %, PC = 25.9 %). BS were significantly more prevalent in both EOP and UHR than PC, and UHR were similar to EOP in symptom domains. Given the uncertain outcome of adolescents at clinical high-risk of psychosis, future research is needed to determine whether the combined assessment of early subjective disturbances with observable APS can improve the accuracy of psychosis prediction.
KW - Adolescents
KW - Basic symptoms
KW - Early detection
KW - Early-onset psychosis
KW - Ultra-high risk
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UR - http://www.scopus.com/inward/citedby.url?scp=84975705280&partnerID=8YFLogxK
U2 - 10.1007/s00787-016-0832-7
DO - 10.1007/s00787-016-0832-7
M3 - Article
C2 - 26921232
AN - SCOPUS:84975705280
SN - 1018-8827
VL - 25
SP - 1091
EP - 1102
JO - European Child and Adolescent Psychiatry
JF - European Child and Adolescent Psychiatry
IS - 10
ER -
