Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid

Yusuke Matoba; Kouji Banno; Iori Kisu; Kosuke Tsuji; Daisuke Aoki

doi:10.1016/j.pdpdt.2019.03.006

Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid

Yusuke Matoba, Kouji Banno, Iori Kisu, Kosuke Tsuji, Daisuke Aoki

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Endometrial cancer is diagnosed by endometrial biopsy, imaging and hysteroscopy, but it is sometimes difficult to find small lesions. 5-aminolevulinic acid (5ALA) forms protoporphyrin IX, which accumulates in tumors and fluoresces upon light irradiation. 5ALA is used for photodynamic diagnosis (PDD) for detecting malignant diseases. A 60-year-old female was suspected to have endometrial cancer by magnetic resonance imaging. Endometrial biopsy was performed repeatedly, but no malignant lesion was detected. We performed hysteroscopic 5ALA-PDD and could detect a small lesion. The lesion was excised and diagnosed as atypical endometrial hyperplasia histopathologically. This is the first report that showed hysteroscopic 5ALA-PDD can contribute to diagnosis of early-stage neoplastic lesion in the uterine cavity.

Original language	English
Pages (from-to)	45-47
Number of pages	3
Journal	Photodiagnosis and Photodynamic Therapy
Volume	26
DOIs	https://doi.org/10.1016/j.pdpdt.2019.03.006
Publication status	Published - 2019 Jun

Keywords

5-Aminolevulinic acid
Endometrial cancer
Endometrial hyperplasia
Hysteroscopy
Photodynamic diagnosis

ASJC Scopus subject areas

Biophysics
Oncology
Dermatology
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pdpdt.2019.03.006

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title = "Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid",

abstract = "Endometrial cancer is diagnosed by endometrial biopsy, imaging and hysteroscopy, but it is sometimes difficult to find small lesions. 5-aminolevulinic acid (5ALA) forms protoporphyrin IX, which accumulates in tumors and fluoresces upon light irradiation. 5ALA is used for photodynamic diagnosis (PDD) for detecting malignant diseases. A 60-year-old female was suspected to have endometrial cancer by magnetic resonance imaging. Endometrial biopsy was performed repeatedly, but no malignant lesion was detected. We performed hysteroscopic 5ALA-PDD and could detect a small lesion. The lesion was excised and diagnosed as atypical endometrial hyperplasia histopathologically. This is the first report that showed hysteroscopic 5ALA-PDD can contribute to diagnosis of early-stage neoplastic lesion in the uterine cavity.",

keywords = "5-Aminolevulinic acid, Endometrial cancer, Endometrial hyperplasia, Hysteroscopy, Photodynamic diagnosis",

author = "Yusuke Matoba and Kouji Banno and Iori Kisu and Kosuke Tsuji and Daisuke Aoki",

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year = "2019",

month = jun,

doi = "10.1016/j.pdpdt.2019.03.006",

language = "English",

volume = "26",

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journal = "Photodiagnosis and Photodynamic Therapy",

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T1 - Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid

AU - Matoba, Yusuke

AU - Banno, Kouji

AU - Kisu, Iori

AU - Tsuji, Kosuke

AU - Aoki, Daisuke

PY - 2019/6

Y1 - 2019/6

N2 - Endometrial cancer is diagnosed by endometrial biopsy, imaging and hysteroscopy, but it is sometimes difficult to find small lesions. 5-aminolevulinic acid (5ALA) forms protoporphyrin IX, which accumulates in tumors and fluoresces upon light irradiation. 5ALA is used for photodynamic diagnosis (PDD) for detecting malignant diseases. A 60-year-old female was suspected to have endometrial cancer by magnetic resonance imaging. Endometrial biopsy was performed repeatedly, but no malignant lesion was detected. We performed hysteroscopic 5ALA-PDD and could detect a small lesion. The lesion was excised and diagnosed as atypical endometrial hyperplasia histopathologically. This is the first report that showed hysteroscopic 5ALA-PDD can contribute to diagnosis of early-stage neoplastic lesion in the uterine cavity.

AB - Endometrial cancer is diagnosed by endometrial biopsy, imaging and hysteroscopy, but it is sometimes difficult to find small lesions. 5-aminolevulinic acid (5ALA) forms protoporphyrin IX, which accumulates in tumors and fluoresces upon light irradiation. 5ALA is used for photodynamic diagnosis (PDD) for detecting malignant diseases. A 60-year-old female was suspected to have endometrial cancer by magnetic resonance imaging. Endometrial biopsy was performed repeatedly, but no malignant lesion was detected. We performed hysteroscopic 5ALA-PDD and could detect a small lesion. The lesion was excised and diagnosed as atypical endometrial hyperplasia histopathologically. This is the first report that showed hysteroscopic 5ALA-PDD can contribute to diagnosis of early-stage neoplastic lesion in the uterine cavity.

KW - 5-Aminolevulinic acid

KW - Endometrial cancer

KW - Endometrial hyperplasia

KW - Hysteroscopy

KW - Photodynamic diagnosis

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ER -

Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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