Auriculol, a cytotoxic oxygenated squalene from the Japanese sea hare Dolabella auricularia: Isolation, stereostructure, and synthesis

Hideo Kigoshi; Takashi Itoh; Takafumi Ogawa; Kenya Ochi; Mayuko Okada; Kiyotake Suenaga; Kiyoyuki Yamada

doi:10.1016/S0040-4039(01)01574-X

Auriculol, a cytotoxic oxygenated squalene from the Japanese sea hare Dolabella auricularia: Isolation, stereostructure, and synthesis

Hideo Kigoshi
, Takashi Itoh
, Takafumi Ogawa
, Kenya Ochi
, Mayuko Okada
, Kiyotake Suenaga
, Kiyoyuki Yamada

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Auriculol, a cytotoxic oxygenated squalene, was isolated from the Japanese sea hare Dolabella auricularia, and its stereostructure was elucidated by spectral analysis and organic synthesis.

Original language	English
Pages (from-to)	7461-7464
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(01)01574-X
Publication status	Published - 2001 Oct 15
Externally published	Yes

Keywords

Cytotoxicity
Dolabella auricularia
Isolation
Sea hare
Stereostructure
Synthesis
Triterpenoid

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01574-X

Cite this

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title = "Auriculol, a cytotoxic oxygenated squalene from the Japanese sea hare Dolabella auricularia: Isolation, stereostructure, and synthesis",

abstract = "Auriculol, a cytotoxic oxygenated squalene, was isolated from the Japanese sea hare Dolabella auricularia, and its stereostructure was elucidated by spectral analysis and organic synthesis.",

keywords = "Cytotoxicity, Dolabella auricularia, Isolation, Sea hare, Stereostructure, Synthesis, Triterpenoid",

author = "Hideo Kigoshi and Takashi Itoh and Takafumi Ogawa and Kenya Ochi and Mayuko Okada and Kiyotake Suenaga and Kiyoyuki Yamada",

note = "Funding Information: We thank Dr. H. Ekimoto and Ms. M. Kimura (Nippon Kayaku Co., Ltd) for the biological testings of 1 . We are grateful to Professor D. Uemura (Nagoya University) for his interests in this work. This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas and for COE Research from the Ministry of Education, Science, Sports, and Culture, Japan. We are indebted to Wako Pure Chemical Industries, Ltd, and Suntory Institute for Bioorganic Research for their financial support. ",

year = "2001",

month = oct,

day = "15",

doi = "10.1016/S0040-4039(01)01574-X",

language = "English",

volume = "42",

pages = "7461--7464",

journal = "Tetrahedron Letters",

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publisher = "Elsevier Ltd",

number = "42",

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TY - JOUR

T1 - Auriculol, a cytotoxic oxygenated squalene from the Japanese sea hare Dolabella auricularia

T2 - Isolation, stereostructure, and synthesis

AU - Kigoshi, Hideo

AU - Itoh, Takashi

AU - Ogawa, Takafumi

AU - Ochi, Kenya

AU - Okada, Mayuko

AU - Suenaga, Kiyotake

AU - Yamada, Kiyoyuki

N1 - Funding Information: We thank Dr. H. Ekimoto and Ms. M. Kimura (Nippon Kayaku Co., Ltd) for the biological testings of 1 . We are grateful to Professor D. Uemura (Nagoya University) for his interests in this work. This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas and for COE Research from the Ministry of Education, Science, Sports, and Culture, Japan. We are indebted to Wako Pure Chemical Industries, Ltd, and Suntory Institute for Bioorganic Research for their financial support.

PY - 2001/10/15

Y1 - 2001/10/15

N2 - Auriculol, a cytotoxic oxygenated squalene, was isolated from the Japanese sea hare Dolabella auricularia, and its stereostructure was elucidated by spectral analysis and organic synthesis.

AB - Auriculol, a cytotoxic oxygenated squalene, was isolated from the Japanese sea hare Dolabella auricularia, and its stereostructure was elucidated by spectral analysis and organic synthesis.

KW - Cytotoxicity

KW - Dolabella auricularia

KW - Isolation

KW - Sea hare

KW - Stereostructure

KW - Synthesis

KW - Triterpenoid

UR - https://www.scopus.com/pages/publications/0035888049

UR - https://www.scopus.com/pages/publications/0035888049#tab=citedBy

U2 - 10.1016/S0040-4039(01)01574-X

DO - 10.1016/S0040-4039(01)01574-X

M3 - Article

AN - SCOPUS:0035888049

SN - 0040-4039

VL - 42

SP - 7461

EP - 7464

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Auriculol, a cytotoxic oxygenated squalene from the Japanese sea hare Dolabella auricularia: Isolation, stereostructure, and synthesis

Abstract

Keywords

ASJC Scopus subject areas

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