Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway

Seiho Nagafuchi; Hitoshi Katsuta; Rimiko Koyanagi-Katsuta; Satoshi Yamasaki; Yasushi Inoue; Kazuya Shimoda; Yukari Ikeda; Mieko Shindo; Eiko Yoshida; Tomohito Matsuo; Yuju Ohno; Kazuhiko Kogawa; Keizo Anzai; Hironori Kurisaki; Jun Kudoh; Mine Harada; Nobuyoshi Shimizu

doi:10.1111/j.1348-0421.2006.tb03876.x

Autoimmune regulator (AIRE) gene is expressed in human activated CD4 ⁺ T-cells and regulated by mitogen-activated protein kinase pathway

Seiho Nagafuchi, Hitoshi Katsuta, Rimiko Koyanagi-Katsuta, Satoshi Yamasaki, Yasushi Inoue, Kazuya Shimoda, Yukari Ikeda, Mieko Shindo, Eiko Yoshida, Tomohito Matsuo, Yuju Ohno, Kazuhiko Kogawa, Keizo Anzai, Hironori Kurisaki, Jun Kudoh, Mine Harada, Nobuyoshi Shimizu

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.

Original language	English
Pages (from-to)	979-987
Number of pages	9
Journal	Microbiology and Immunology
Volume	50
Issue number	12
DOIs	https://doi.org/10.1111/j.1348-0421.2006.tb03876.x
Publication status	Published - 2006
Externally published	Yes

Keywords

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Autoimmune regulator (AIRE)
Autoimmunity
Interleukin-2
T lymphocytes

ASJC Scopus subject areas

Microbiology
Immunology
Virology

Access to Document

10.1111/j.1348-0421.2006.tb03876.x

Cite this

Nagafuchi, S., Katsuta, H., Koyanagi-Katsuta, R., Yamasaki, S., Inoue, Y., Shimoda, K., Ikeda, Y., Shindo, M., Yoshida, E., Matsuo, T., Ohno, Y., Kogawa, K., Anzai, K., Kurisaki, H., Kudoh, J., Harada, M., & Shimizu, N. (2006). Autoimmune regulator (AIRE) gene is expressed in human activated CD4 ⁺ T-cells and regulated by mitogen-activated protein kinase pathway. Microbiology and Immunology, 50(12), 979-987. https://doi.org/10.1111/j.1348-0421.2006.tb03876.x

Nagafuchi, S, Katsuta, H, Koyanagi-Katsuta, R, Yamasaki, S, Inoue, Y, Shimoda, K, Ikeda, Y, Shindo, M, Yoshida, E, Matsuo, T, Ohno, Y, Kogawa, K, Anzai, K, Kurisaki, H, Kudoh, J, Harada, M & Shimizu, N 2006, 'Autoimmune regulator (AIRE) gene is expressed in human activated CD4 ⁺ T-cells and regulated by mitogen-activated protein kinase pathway', Microbiology and Immunology, vol. 50, no. 12, pp. 979-987. https://doi.org/10.1111/j.1348-0421.2006.tb03876.x

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abstract = "The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.",

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author = "Seiho Nagafuchi and Hitoshi Katsuta and Rimiko Koyanagi-Katsuta and Satoshi Yamasaki and Yasushi Inoue and Kazuya Shimoda and Yukari Ikeda and Mieko Shindo and Eiko Yoshida and Tomohito Matsuo and Yuju Ohno and Kazuhiko Kogawa and Keizo Anzai and Hironori Kurisaki and Jun Kudoh and Mine Harada and Nobuyoshi Shimizu",

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AU - Katsuta, Hitoshi

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AU - Yamasaki, Satoshi

AU - Inoue, Yasushi

AU - Shimoda, Kazuya

AU - Ikeda, Yukari

AU - Shindo, Mieko

AU - Yoshida, Eiko

AU - Matsuo, Tomohito

AU - Ohno, Yuju

AU - Kogawa, Kazuhiko

AU - Anzai, Keizo

AU - Kurisaki, Hironori

AU - Kudoh, Jun

AU - Harada, Mine

AU - Shimizu, Nobuyoshi

PY - 2006

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N2 - The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.

AB - The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.

KW - Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)

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KW - T lymphocytes

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