TY - JOUR
T1 - Autophagy in the placenta of women with hypertensive disorders in pregnancy
AU - Akaishi, R.
AU - Yamada, T.
AU - Nakabayashi, K.
AU - Nishihara, H.
AU - Furuta, I.
AU - Kojima, T.
AU - Morikawa, M.
AU - Fujita, N.
AU - Minakami, H.
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan (No. 18791140 and No. 26462468 ), by grants from the Takeda Scientific Foundation , and by the JAOG Ogyaa Donation Foundation .
Publisher Copyright:
Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Introduction: Autophagy has not been studied extensively in the human placenta. This study was performed to determine whether autophagy is increased in the placentas of women with hypertensive disorders in pregnancy compared to normotensive pregnancies. Methods: LC3-II and p62 protein expression were examined by quantitative Western blotting analysis in 40 placentas from women not experiencing labor pains. The 40 placentas were from 13, 8, and 19 women with preeclampsia, gestational hypertension, and normal pregnancy, respectively. Hypertensive disorders in pregnancy included preeclampsia and gestational hypertension. Results: LC3-II expression was significantly increased, while that of p62 was significantly reduced in 21 placentas of women with hypertensive disorders compared to those with normal blood pressure irrespective of the presence or absence of fetal growth restriction (FGR). LC3-II expression was also significantly increased in 13 placentas of women with preeclampsia irrespective of the presence or absence of FGR. Discussion: The results of this study suggested that autophagy is active in the placenta of hypertensive disorders even in the absence of FGR.
AB - Introduction: Autophagy has not been studied extensively in the human placenta. This study was performed to determine whether autophagy is increased in the placentas of women with hypertensive disorders in pregnancy compared to normotensive pregnancies. Methods: LC3-II and p62 protein expression were examined by quantitative Western blotting analysis in 40 placentas from women not experiencing labor pains. The 40 placentas were from 13, 8, and 19 women with preeclampsia, gestational hypertension, and normal pregnancy, respectively. Hypertensive disorders in pregnancy included preeclampsia and gestational hypertension. Results: LC3-II expression was significantly increased, while that of p62 was significantly reduced in 21 placentas of women with hypertensive disorders compared to those with normal blood pressure irrespective of the presence or absence of fetal growth restriction (FGR). LC3-II expression was also significantly increased in 13 placentas of women with preeclampsia irrespective of the presence or absence of FGR. Discussion: The results of this study suggested that autophagy is active in the placenta of hypertensive disorders even in the absence of FGR.
KW - Autophagy
KW - Gestational hypertension
KW - Preeclampsia
KW - Pregnancy-induced hypertension
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U2 - 10.1016/j.placenta.2014.10.009
DO - 10.1016/j.placenta.2014.10.009
M3 - Article
C2 - 25465707
AN - SCOPUS:84922414962
SN - 0143-4004
VL - 35
SP - 974
EP - 980
JO - Placenta
JF - Placenta
IS - 12
ER -