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Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging

Research output: Contribution to journalArticlepeer-review

Abstract

The C4N4 fluorophore is an intense fluorescence emitter featuring a 2,5-diaminopyrimidine core comprising four carbon and four nitrogen atoms. A series of C4N4 derivatives was photochemically dimerized at the 5-amino group, furnishing overcrowded orthotetraaryl-substituted diaryl azo compounds with a characteristic skewed structure revealed by X-ray crystallography. The photo-quenched azo-C4N4s are useful for fluorescently visualizing cells under hypoxic conditions.

Original languageEnglish
Pages (from-to)2889-2893
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume21
Issue number14
DOIs
Publication statusPublished - 2023 Jan 30

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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