Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

Mariko Yokogawa; Takahiro Muramatsu; Koh Takeuchi; Masanori Osawa; Ichio Shimada

doi:10.1007/s12104-009-9156-6

Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

Mariko Yokogawa, Takahiro Muramatsu, Koh Takeuchi, Masanori Osawa, Ichio Shimada

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein βγ subunits (Gβγ), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of ²H/¹³C/¹⁵N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.

Original language	English
Pages (from-to)	125-128
Number of pages	4
Journal	Biomolecular NMR Assignments
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s12104-009-9156-6
Publication status	Published - 2009 Jun
Externally published	Yes

Keywords

GIRK
Inwardly rectifying potassium channel
Ion transport
Tetramer

ASJC Scopus subject areas

Structural Biology
Biochemistry

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10.1007/s12104-009-9156-6

Cite this

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abstract = "G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein βγ subunits (Gβγ), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of 2H/13C/15N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.",

keywords = "GIRK, Inwardly rectifying potassium channel, Ion transport, Tetramer",

author = "Mariko Yokogawa and Takahiro Muramatsu and Koh Takeuchi and Masanori Osawa and Ichio Shimada",

note = "Funding Information: Acknowledgments This work was supported in part by grants from the Japan New Energy and Industrial Technology Development Organization (NEDO) and the Ministry of Economy, Trade, and Industry (METI) (to I.S.). M.Y. is a research fellow of the Japan Society for the Promotion of Science (JSPS).",

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doi = "10.1007/s12104-009-9156-6",

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T1 - Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

AU - Yokogawa, Mariko

AU - Muramatsu, Takahiro

AU - Takeuchi, Koh

AU - Osawa, Masanori

AU - Shimada, Ichio

N1 - Funding Information: Acknowledgments This work was supported in part by grants from the Japan New Energy and Industrial Technology Development Organization (NEDO) and the Ministry of Economy, Trade, and Industry (METI) (to I.S.). M.Y. is a research fellow of the Japan Society for the Promotion of Science (JSPS).

PY - 2009/6

Y1 - 2009/6

N2 - G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein βγ subunits (Gβγ), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of 2H/13C/15N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.

AB - G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein βγ subunits (Gβγ), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of 2H/13C/15N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.

KW - GIRK

KW - Inwardly rectifying potassium channel

KW - Ion transport

KW - Tetramer

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Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

Abstract

Keywords

ASJC Scopus subject areas

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