Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma

Akiko Hori; Masahiro Kami; Sung Won Kim; Atsushi Makimoto; Ryuji Tanosaki; Yoichi Takaue

doi:10.1038/sj.thj.6200371

Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma

Akiko Hori, Masahiro Kami, Sung Won Kim, Atsushi Makimoto, Ryuji Tanosaki, Yoichi Takaue

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.

Original language	English
Pages (from-to)	276-278
Number of pages	3
Journal	Hematology Journal
Volume	5
Issue number	3
DOIs	https://doi.org/10.1038/sj.thj.6200371
Publication status	Published - 2004
Externally published	Yes

Keywords

Acute graft-versus-host diasease
Corticosteroid
Graft-versus-tumor effect
Reduced-intensity stem cell transplantation
Renal cell carcinoma

ASJC Scopus subject areas

Hematology

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10.1038/sj.thj.6200371

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title = "Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma",

abstract = "We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.",

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T1 - Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma

AU - Hori, Akiko

AU - Kami, Masahiro

AU - Kim, Sung Won

AU - Makimoto, Atsushi

AU - Tanosaki, Ryuji

AU - Takaue, Yoichi

PY - 2004

Y1 - 2004

N2 - We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.

AB - We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.

KW - Acute graft-versus-host diasease

KW - Corticosteroid

KW - Graft-versus-tumor effect

KW - Reduced-intensity stem cell transplantation

KW - Renal cell carcinoma

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Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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