Basal ganglia correlates of fatigue in young adults

Seishu Nakagawa; Hikaru Takeuchi; Yasuyuki Taki; Rui Nouchi; Yuka Kotozaki; Takamitsu Shinada; Tsukasa Maruyama; Atsushi Sekiguchi; Kunio Iizuka; Ryoichi Yokoyama; Yuki Yamamoto; Sugiko Hanawa; Tsuyoshi Araki; Carlos Makoto Miyauchi; Daniele Magistro; Kohei Sakaki; Hyeonjeong Jeong; Yukako Sasaki; Ryuta Kawashima

doi:10.1038/srep21386

Basal ganglia correlates of fatigue in young adults

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.

Original language	English
Article number	21386
Journal	Scientific reports
Volume	6
DOIs	https://doi.org/10.1038/srep21386
Publication status	Published - 2016 Feb 19
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/srep21386

Cite this

Nakagawa, S., Takeuchi, H., Taki, Y., Nouchi, R., Kotozaki, Y., Shinada, T., Maruyama, T., Sekiguchi, A., Iizuka, K., Yokoyama, R., Yamamoto, Y., Hanawa, S., Araki, T., Miyauchi, C. M., Magistro, D., Sakaki, K., Jeong, H., Sasaki, Y., & Kawashima, R. (2016). Basal ganglia correlates of fatigue in young adults. Scientific reports, 6, Article 21386. https://doi.org/10.1038/srep21386

@article{a2dabb5e2a2e4ac283e82957d2d2ea2e,

title = "Basal ganglia correlates of fatigue in young adults",

abstract = "Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.",

author = "Seishu Nakagawa and Hikaru Takeuchi and Yasuyuki Taki and Rui Nouchi and Yuka Kotozaki and Takamitsu Shinada and Tsukasa Maruyama and Atsushi Sekiguchi and Kunio Iizuka and Ryoichi Yokoyama and Yuki Yamamoto and Sugiko Hanawa and Tsuyoshi Araki and Miyauchi, {Carlos Makoto} and Daniele Magistro and Kohei Sakaki and Hyeonjeong Jeong and Yukako Sasaki and Ryuta Kawashima",

note = "Funding Information: Dr. S. N. was supported by Health Science Center Foundation (H25). Dr. H.T. was supported by JST/RISTEX, JST/CREST, a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306), a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology, and Health Science Center Foundation. We respectfully thank Yuki Yamada for operating the MRI scanner and Haruka Nouchi for administering the psychological tests. Furthermore, we would like to thank the participants in the study, the other individuals who administered psychological tests, and our colleagues in the Institute of Development, Ageing and Cancer at Tohoku University for their support.",

year = "2016",

month = feb,

day = "19",

doi = "10.1038/srep21386",

language = "English",

volume = "6",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Basal ganglia correlates of fatigue in young adults

AU - Nakagawa, Seishu

AU - Takeuchi, Hikaru

AU - Taki, Yasuyuki

AU - Nouchi, Rui

AU - Kotozaki, Yuka

AU - Shinada, Takamitsu

AU - Maruyama, Tsukasa

AU - Sekiguchi, Atsushi

AU - Iizuka, Kunio

AU - Yokoyama, Ryoichi

AU - Yamamoto, Yuki

AU - Hanawa, Sugiko

AU - Araki, Tsuyoshi

AU - Miyauchi, Carlos Makoto

AU - Magistro, Daniele

AU - Sakaki, Kohei

AU - Jeong, Hyeonjeong

AU - Sasaki, Yukako

AU - Kawashima, Ryuta

N1 - Funding Information: Dr. S. N. was supported by Health Science Center Foundation (H25). Dr. H.T. was supported by JST/RISTEX, JST/CREST, a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306), a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology, and Health Science Center Foundation. We respectfully thank Yuki Yamada for operating the MRI scanner and Haruka Nouchi for administering the psychological tests. Furthermore, we would like to thank the participants in the study, the other individuals who administered psychological tests, and our colleagues in the Institute of Development, Ageing and Cancer at Tohoku University for their support.

PY - 2016/2/19

Y1 - 2016/2/19

N2 - Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.

AB - Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.

UR - http://www.scopus.com/inward/record.url?scp=84958998907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958998907&partnerID=8YFLogxK

U2 - 10.1038/srep21386

DO - 10.1038/srep21386

M3 - Article

C2 - 26893077

AN - SCOPUS:84958998907

SN - 2045-2322

VL - 6

JO - Scientific reports

JF - Scientific reports

M1 - 21386

ER -

Basal ganglia correlates of fatigue in young adults

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this