Basic studies on the stability of flavored oral solutions of rebamipide

Ryo Yajima, Futa Imaoka, Tetsuya Wako, Yuko Kuroda, Kazuaki Matsumoto, Junko Kizu, Shiro Katayama

Research output: Contribution to journalComment/debatepeer-review


Stomatitis frequently occurs during chemotherapy and radiotherapy for cancer. Because of its pharmacological properties including anti-inflammatory activity and stimulatory effects on endogenous prostaglandin synthesis, rebamipide has been suggested as a potentially effective treatment against stomatitis. In the present study we tested the stability of oral rebamipide solutions prepared in our hospital pharmacy using sodium alginate as a thickener to increase retention of this agent in the oral cavity, and the addition of different flavoring mixtures intended for use in enteral diets to reduce the bitterness of rebamipide and sodium alginate. Samples of oral rebamipide solution prepared with 13 kinds of flavoring and sodium alginate were evaluated in terms of their appearance, redispersibility, pH, viscosity, and rebamipide content immediately after preparation and 1, 3, 7, and 10 days after storage at room temperature under ambient light or in a cool, dark place. After 10 days of storage, favorable stability was observed in four sample solutions supplemented with green apple, pineapple, yogurt, and tomato flavoring mixtures intended for use in Elental® diets. These oral solutions may have potential clinical application.

Original languageEnglish
Pages (from-to)1397-1402
Number of pages6
JournalYakugaku Zasshi
Issue number12
Publication statusPublished - 2015 Dec 1


  • Flavor
  • Rebamipide
  • Sodium alginate
  • Stability
  • Stomatitis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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