Beta-cell mass in obesity and type 2 diabetes, and its relation to pancreas fat: A mini-review

Jun Inaishi, Yoshifumi Saisho

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


Type 2 diabetes (T2DM) is characterized by insulin resistance and beta-cell dysfunction. Although insulin resistance is assumed to be a main pathophysiological feature of the development of T2DM, recent studies have revealed that a deficit of functional beta-cell mass is an essential factor for the pathophysiology of T2DM. Pancreatic fat contents increase with obesity and are suggested to cause beta-cell dysfunction. Since the beta-cell dysfunction induced by obesity or progressive decline with disease duration results in a worsening glycemic control, and treatment failure, preserving beta-cell mass is an important treatment strategy for T2DM. In this mini-review, we summarize the current knowledge on beta-cell mass, beta-cell function, and pancreas fat in obesity and T2DM, and we discuss treatment strategies for T2DM in relation to beta-cell preservation.

Original languageEnglish
Article number3846
Pages (from-to)1-16
Number of pages16
Issue number12
Publication statusPublished - 2020 Dec


  • Beta-cell mass
  • Diabetes
  • Human pancreas
  • Obesity
  • Pancreas fat

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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