TY - JOUR
T1 - Biliary reconstruction in pediatric live donor liver transplantation
T2 - Duct-to-duct or Roux-en-Y hepaticojejunostomy
AU - Tanaka, Hideaki
AU - Fukuda, Akinari
AU - Shigeta, Takanobu
AU - Kuroda, Tatsuo
AU - Kimura, Takuya
AU - Sakamoto, Seisuke
AU - Kasahara, Mureo
PY - 2010/8/1
Y1 - 2010/8/1
N2 - Background: Duct-to-duct biliary reconstruction (DD) is currently a standard procedure in adult live donor liver transplantation (LDLT). Its pediatric feasibility, however, has rarely been reported. The goal of this study is to assess the incidence and treatment of biliary complication after pediatric LDLT with DD or Roux-en-Y hepaticojejunostomy (RY). Method: Sixty children received LDLT between November 2005 and June 2008, and their database was reviewed. Results: Biliary reconstruction was achieved with DD in 14 patients and with RY in 46 patients with mean follow-up period of 26.0 and 22.3 months, respectively. The incidence of biliary leakage in the DD and RY groups was 7.1% and 8.7%, respectively, and that of stricture was 28.6% and 10.9%, respectively; but the differences were not statistically significant. Biliary stricture in the DD group tended to require revision surgery with RY and longer treatment with percutaneous transhepatic cholangiodrainage compared with that in the RY group. Conclusion: Theoretical advantages of DD over RY were not confirmed in this study. Duct-to-duct biliary reconstruction tended to encounter more biliary complications, especially stricture, with more difficulty in treating it than RY. Roux-en-Y hepaticojejunostomy seems preferable to DD in the setting of pediatric LDLT, but DD must be considered when making new Roux-en-Y limb seems impossible or troublesome owing to abdominal dense adhesion or short bowel syndrome.
AB - Background: Duct-to-duct biliary reconstruction (DD) is currently a standard procedure in adult live donor liver transplantation (LDLT). Its pediatric feasibility, however, has rarely been reported. The goal of this study is to assess the incidence and treatment of biliary complication after pediatric LDLT with DD or Roux-en-Y hepaticojejunostomy (RY). Method: Sixty children received LDLT between November 2005 and June 2008, and their database was reviewed. Results: Biliary reconstruction was achieved with DD in 14 patients and with RY in 46 patients with mean follow-up period of 26.0 and 22.3 months, respectively. The incidence of biliary leakage in the DD and RY groups was 7.1% and 8.7%, respectively, and that of stricture was 28.6% and 10.9%, respectively; but the differences were not statistically significant. Biliary stricture in the DD group tended to require revision surgery with RY and longer treatment with percutaneous transhepatic cholangiodrainage compared with that in the RY group. Conclusion: Theoretical advantages of DD over RY were not confirmed in this study. Duct-to-duct biliary reconstruction tended to encounter more biliary complications, especially stricture, with more difficulty in treating it than RY. Roux-en-Y hepaticojejunostomy seems preferable to DD in the setting of pediatric LDLT, but DD must be considered when making new Roux-en-Y limb seems impossible or troublesome owing to abdominal dense adhesion or short bowel syndrome.
KW - Complication
KW - Duct-to-duct biliary reconstruction
KW - Live donor liver transplantation
KW - Pediatric
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U2 - 10.1016/j.jpedsurg.2010.03.010
DO - 10.1016/j.jpedsurg.2010.03.010
M3 - Article
C2 - 20713218
AN - SCOPUS:77955891302
SN - 0022-3468
VL - 45
SP - 1668
EP - 1675
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 8
ER -