Binding affinity of GM3 lactone for influenza virus

Toshinori Sato; Megumi Ishii; Fuyuka Ohtake; Kyosuke Nagata; Takashi Terabayashi; Yasuhiro Kawanishi; Yoshio Okahata

doi:10.1023/A:1007028421092

Binding affinity of GM3 lactone for influenza virus

Toshinori Sato, Megumi Ishii, Fuyuka Ohtake, Kyosuke Nagata, Takashi Terabayashi, Yasuhiro Kawanishi, Yoshio Okahata

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We investigated the interaction of GM3 lactone with influenza virus. The specific bindings of influenza virus and its hemagglutinin to GM3 lactone-containing mixed monolayers were studied by using a quartz-crystal microbalance. It has been known that gangliosides as receptors for influenza virus are also substrates for virus neuraminidase. GM3 lactone, however, was found to bind to influenza virus hemagglutinin, but not to be substrate for virus neuraminidase.

Original language	English
Pages (from-to)	223-227
Number of pages	5
Journal	Glycoconjugate Journal
Volume	16
Issue number	3
DOIs	https://doi.org/10.1023/A:1007028421092
Publication status	Published - 1999 Oct 18
Externally published	Yes

Keywords

Air-water interface monolayer
GM3
GM3 lactone
Hemagglutinin
Influenza virus
Quartz-crystal microbalance

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1023/A:1007028421092

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T1 - Binding affinity of GM3 lactone for influenza virus

AU - Sato, Toshinori

AU - Ishii, Megumi

AU - Ohtake, Fuyuka

AU - Nagata, Kyosuke

AU - Terabayashi, Takashi

AU - Kawanishi, Yasuhiro

AU - Okahata, Yoshio

PY - 1999/10/18

Y1 - 1999/10/18

N2 - We investigated the interaction of GM3 lactone with influenza virus. The specific bindings of influenza virus and its hemagglutinin to GM3 lactone-containing mixed monolayers were studied by using a quartz-crystal microbalance. It has been known that gangliosides as receptors for influenza virus are also substrates for virus neuraminidase. GM3 lactone, however, was found to bind to influenza virus hemagglutinin, but not to be substrate for virus neuraminidase.

AB - We investigated the interaction of GM3 lactone with influenza virus. The specific bindings of influenza virus and its hemagglutinin to GM3 lactone-containing mixed monolayers were studied by using a quartz-crystal microbalance. It has been known that gangliosides as receptors for influenza virus are also substrates for virus neuraminidase. GM3 lactone, however, was found to bind to influenza virus hemagglutinin, but not to be substrate for virus neuraminidase.

KW - Air-water interface monolayer

KW - GM3

KW - GM3 lactone

KW - Hemagglutinin

KW - Influenza virus

KW - Quartz-crystal microbalance

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Binding affinity of GM3 lactone for influenza virus

Abstract

Keywords

ASJC Scopus subject areas

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