Biocatalysis in Organic Synthesis: The Use of Nitrile- and Amide-hydrolyzing Microorganisms

Takeshi Sugai; Takahiro Yamazaki; Masahiro Yokoyama; Hiromichi Ohta

doi:10.1271/bbb.61.1419

Biocatalysis in Organic Synthesis: The Use of Nitrile- and Amide-hydrolyzing Microorganisms

Takeshi Sugai, Takahiro Yamazaki, Masahiro Yokoyama, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

132 Citations (Scopus)

Abstract

This review covers recent examples of synthetic transformation of nitriles and amides by microbial enzyme systems. A variety of substrates and products involving enantiomerically enriched forms of chiral substances are referred to. The stereochemical course of enzyme-catalyzed hydrolysis is briefly commented on. Special emphasis is placed upon the range of functional groups that are acceptable by enzymes and/or survive under the transformation, as well as the advantages as a synthetic tool for conversion under mild conditions.

Original language	English
Pages (from-to)	1419-1427
Number of pages	9
Journal	Bioscience, Biotechnology and Biochemistry
Volume	61
Issue number	9
DOIs	https://doi.org/10.1271/bbb.61.1419
Publication status	Published - 1997 Jan

Keywords

Amide
Hydrolysis
Microorganisms
Nitrile
Organic synthesis

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.61.1419

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Biocatalysis in Organic Synthesis: The Use of Nitrile- and Amide-hydrolyzing Microorganisms

Abstract

Keywords

ASJC Scopus subject areas

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