Biocatalysis in Organic Synthesis: The Use of Nitrile- and Amide-hydrolyzing Microorganisms

Takeshi Sugai, Takahiro Yamazaki, Masahiro Yokoyama, Hiromichi Ohta

Research output: Contribution to journalArticlepeer-review

132 Citations (Scopus)


This review covers recent examples of synthetic transformation of nitriles and amides by microbial enzyme systems. A variety of substrates and products involving enantiomerically enriched forms of chiral substances are referred to. The stereochemical course of enzyme-catalyzed hydrolysis is briefly commented on. Special emphasis is placed upon the range of functional groups that are acceptable by enzymes and/or survive under the transformation, as well as the advantages as a synthetic tool for conversion under mild conditions.

Original languageEnglish
Pages (from-to)1419-1427
Number of pages9
JournalBioscience, Biotechnology and Biochemistry
Issue number9
Publication statusPublished - 1997 Jan


  • Amide
  • Hydrolysis
  • Microorganisms
  • Nitrile
  • Organic synthesis

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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