Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue

Keisuke Okita; Midori Kato-Negishi; Hiroaki Onoe; Riho Gojo; Tetsuhiko Teshima; Shoji Takeuchi

Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue

Keisuke Okita, Midori Kato-Negishi, Hiroaki Onoe, Riho Gojo, Tetsuhiko Teshima, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We propose a neural probe combined with a neuronal spheroid (neurospheroid) cultured on electrodes for deep brain stimulation. Since neurons of the spheroid extend their axons deep into the brain tissue, the neural probe can electrically stimulate deep brain area via the neurons without inserting an invasive probe. Here we first fabricated an electrode and then successfully placed a neurospheorid at the electrodes tip, named a "biohybrid neural probe". Furthermore, we tried to make the fabricated probe contact with cultured cortical cells on glass. We believe that our biohybrid neural probe has a potential to provide minimally invasive stimulation to the brain tissue.

Original language	English
Title of host publication	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages	332-334
Number of pages	3
Publication status	Published - 2011 Dec 1
Externally published	Yes
Event	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States Duration: 2011 Oct 2 → 2011 Oct 6

Publication series

Name	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume	1

Other

Other	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Country/Territory	United States
City	Seattle, WA
Period	11/10/2 → 11/10/6

Keywords

Deep brain stimulation
Electrode
Neural probe
Neurospheroid
Spheroid

ASJC Scopus subject areas

Control and Systems Engineering

Cite this

Okita, K., Kato-Negishi, M., Onoe, H., Gojo, R., Teshima, T., & Takeuchi, S. (2011). Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 332-334). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).

Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue. / Okita, Keisuke; Kato-Negishi, Midori; Onoe, Hiroaki et al.
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. p. 332-334 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Okita, K, Kato-Negishi, M, Onoe, H, Gojo, R, Teshima, T & Takeuchi, S 2011, Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, vol. 1, pp. 332-334, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 11/10/2.

Okita K, Kato-Negishi M, Onoe H, Gojo R, Teshima T, Takeuchi S. Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. p. 332-334. (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

Okita, Keisuke ; Kato-Negishi, Midori ; Onoe, Hiroaki et al. / Biohybrid neural probe : A neural probe having cultured neurons between an electrode and tissue. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. pp. 332-334 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

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AB - We propose a neural probe combined with a neuronal spheroid (neurospheroid) cultured on electrodes for deep brain stimulation. Since neurons of the spheroid extend their axons deep into the brain tissue, the neural probe can electrically stimulate deep brain area via the neurons without inserting an invasive probe. Here we first fabricated an electrode and then successfully placed a neurospheorid at the electrodes tip, named a "biohybrid neural probe". Furthermore, we tried to make the fabricated probe contact with cultured cortical cells on glass. We believe that our biohybrid neural probe has a potential to provide minimally invasive stimulation to the brain tissue.

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Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue

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Keywords

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