A series of methylene-bridged phenolic oligomers was prepared and the minimal inhibitory concentrations against bacteria and fungi were determined by agar dilution method. These compounds proved to be greatly effective against gram-positive bacteria and fungi. Homogeneous all ortho methylene-bridged phenolic oligomers were synthesized and the effect of the degree of addition-condensation on antimicrobial potency was examined. Of the homogeneous oligomers, tetramers were the most active against gram-positive bacteria, and trimers showed good antimicrobial activity against fungi.
|Number of pages||4|
|Journal||Journal of Antibacterial and Antifungal Agents, Japan|
|Publication status||Published - 1990 Jan 1|
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