Biological activities of unique isoflavones prepared from Apios americana Medik

Haruna Kaneta, Mina Koda, Shun Saito, Masaya Imoto, Manabu Kawada, Yoko Yamazaki, Isao Momose, Kazuoshi Shindo

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Four unique isoflavone aglycones (barpisoflavone A (1), 2′-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1.4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.

Original languageEnglish
Pages (from-to)774-778
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Issue number4
Publication statusPublished - 2016


  • Antioxidant activity
  • Apios americana Medik
  • Estrogen agonistic activity
  • Isoflavone
  • α-glucosidase inhibitory activity

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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