Biological agents targeting on pro-inflammatory cytokines

Tsutomu Takeuchi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Biological agents targeting on pro-inflammatory cytokines are developed, and provide a great impact on the medical management of rheumatoid arthritis (RA). Particularly, biologics against tumor necrosis factor(TNF) can not only induce great clinical improvement, but also halt structural damage on the joints. Now chimeric anti-TNFalpha monoclonal antibody, infliximab, full human anti-TNFalpha monoclonal antibody, adalimumab, and TNF receptor II (p75) -IgGFc fusion protein, etanercept, are widely used in the inflammatory disorders including RA. This review article shows the characteristics of these anti-TNF biologics on RA, and summarizes the efficacy as well as the safety of the agents.

Original languageEnglish
Pages (from-to)1601-1606
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number9
Publication statusPublished - 2005 Sept
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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