Biological and therapeutic significance of MUC1 with sialoglycans in clear cell adenocarcinoma of the ovary

Yutaka Tamada; Hideyuki Takeuchi; Nao Suzuki; Nobuyuki Susumu; Daisuke Aoki; Tatsuro Irimura

doi:10.1111/j.1349-7006.2007.00582.x

Biological and therapeutic significance of MUC1 with sialoglycans in clear cell adenocarcinoma of the ovary

Yutaka Tamada, Hideyuki Takeuchi, Nao Suzuki, Nobuyuki Susumu, Daisuke Aoki, Tatsuro Irimura

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A monoclonal antibody (mAb) MY.1E12 was applied to detect MUC1 with sialylated glycans in a total of 55 formalin-fixed, paraffin-embedded surgical specimens of ovarian clear cell adenocarcinomas. A reverse correlation between the binding levels of this mAb and patient survival was demonstrated. To examine the role of MUC1 in ovarian clear cell carcinomas, two cDNA encoding MUC1 were transfected into ES-2 ovarian clear cell carcinoma cells. By comparing these cells, the role of MUC1 in tumorigenicity, chemosensitivity and survival under anoikis conditions were assessed. The results indicate that MUC1 expressed on ovarian clear cell carcinoma cells is causally involved in the malignant behavior.

Original language	English
Pages (from-to)	1586-1591
Number of pages	6
Journal	Cancer science
Volume	98
Issue number	10
DOIs	https://doi.org/10.1111/j.1349-7006.2007.00582.x
Publication status	Published - 2007 Oct

ASJC Scopus subject areas

Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.2007.00582.x

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abstract = "A monoclonal antibody (mAb) MY.1E12 was applied to detect MUC1 with sialylated glycans in a total of 55 formalin-fixed, paraffin-embedded surgical specimens of ovarian clear cell adenocarcinomas. A reverse correlation between the binding levels of this mAb and patient survival was demonstrated. To examine the role of MUC1 in ovarian clear cell carcinomas, two cDNA encoding MUC1 were transfected into ES-2 ovarian clear cell carcinoma cells. By comparing these cells, the role of MUC1 in tumorigenicity, chemosensitivity and survival under anoikis conditions were assessed. The results indicate that MUC1 expressed on ovarian clear cell carcinoma cells is causally involved in the malignant behavior.",

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AU - Tamada, Yutaka

AU - Takeuchi, Hideyuki

AU - Suzuki, Nao

AU - Susumu, Nobuyuki

AU - Aoki, Daisuke

AU - Irimura, Tatsuro

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Biological and therapeutic significance of MUC1 with sialoglycans in clear cell adenocarcinoma of the ovary

Abstract

ASJC Scopus subject areas

UN SDGs

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