Biological evaluation of chelate-setting apatite cement using inositol phosphate

K. Kida; Y. Horiguchf; K. Oribe; H. Morisue; M. Matsumoto; Y. Toyama; M. Aizawa

Biological evaluation of chelate-setting apatite cement using inositol phosphate

K. Kida, Y. Horiguchf, K. Oribe, H. Morisue, M. Matsumoto, Y. Toyama, M. Aizawa

Research output: Contribution to journal › Article › peer-review

Abstract

We have successfully developed novel "chelate-setting apatite cement" using hydroxyapatite (HAp) particles surface-modified with inositol phosphate (IP₆) . The HAp particles surface-modified with IP ₆ were mixed with water (HAp/water ratio = 1.00/0.50[w/w]) to fabricate apatite cements. We have examined the biocompatibility of the apatite cement using the culture system of MC3T3-E1 cells and the rabbit model. The cell-culture test using MC3T3-E1 cells has shown that the apatite cement has noncytotoxicity. This cement has been implanted into tibiae of rabbits. When tissue response was examined histologically up to 24 weeks, new bone formation was observed around the surface of the cement. The present work demonstrates that this apatite cement is useful as a material for artificial bone grafting.

Original language	English
Pages (from-to)	335-338
Number of pages	4
Journal	Key Engineering Materials
Volume	361-363 I
Publication status	Published - 2008

Keywords

Biocompatibility
Cement
Hydroxyapatite
Inositol phosphate

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Biological evaluation of chelate-setting apatite cement using inositol phosphate",

abstract = "We have successfully developed novel {"}chelate-setting apatite cement{"} using hydroxyapatite (HAp) particles surface-modified with inositol phosphate (IP6) . The HAp particles surface-modified with IP 6 were mixed with water (HAp/water ratio = 1.00/0.50[w/w]) to fabricate apatite cements. We have examined the biocompatibility of the apatite cement using the culture system of MC3T3-E1 cells and the rabbit model. The cell-culture test using MC3T3-E1 cells has shown that the apatite cement has noncytotoxicity. This cement has been implanted into tibiae of rabbits. When tissue response was examined histologically up to 24 weeks, new bone formation was observed around the surface of the cement. The present work demonstrates that this apatite cement is useful as a material for artificial bone grafting.",

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year = "2008",

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T1 - Biological evaluation of chelate-setting apatite cement using inositol phosphate

AU - Kida, K.

AU - Horiguchf, Y.

AU - Oribe, K.

AU - Morisue, H.

AU - Matsumoto, M.

AU - Toyama, Y.

AU - Aizawa, M.

PY - 2008

Y1 - 2008

N2 - We have successfully developed novel "chelate-setting apatite cement" using hydroxyapatite (HAp) particles surface-modified with inositol phosphate (IP6) . The HAp particles surface-modified with IP 6 were mixed with water (HAp/water ratio = 1.00/0.50[w/w]) to fabricate apatite cements. We have examined the biocompatibility of the apatite cement using the culture system of MC3T3-E1 cells and the rabbit model. The cell-culture test using MC3T3-E1 cells has shown that the apatite cement has noncytotoxicity. This cement has been implanted into tibiae of rabbits. When tissue response was examined histologically up to 24 weeks, new bone formation was observed around the surface of the cement. The present work demonstrates that this apatite cement is useful as a material for artificial bone grafting.

AB - We have successfully developed novel "chelate-setting apatite cement" using hydroxyapatite (HAp) particles surface-modified with inositol phosphate (IP6) . The HAp particles surface-modified with IP 6 were mixed with water (HAp/water ratio = 1.00/0.50[w/w]) to fabricate apatite cements. We have examined the biocompatibility of the apatite cement using the culture system of MC3T3-E1 cells and the rabbit model. The cell-culture test using MC3T3-E1 cells has shown that the apatite cement has noncytotoxicity. This cement has been implanted into tibiae of rabbits. When tissue response was examined histologically up to 24 weeks, new bone formation was observed around the surface of the cement. The present work demonstrates that this apatite cement is useful as a material for artificial bone grafting.

KW - Biocompatibility

KW - Cement

KW - Hydroxyapatite

KW - Inositol phosphate

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SN - 1013-9826

VL - 361-363 I

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EP - 338

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

Biological evaluation of chelate-setting apatite cement using inositol phosphate

Abstract

Keywords

ASJC Scopus subject areas

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