Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium lyngbya sp.: Isolation, stereostructure, and biological activity

Toshiaki Teruya; Hiroaki Sasaki; Hidesuke Fukazawa; Kiyotake Suenaga

doi:10.1021/ol9020546

Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium lyngbya sp. Isolation, stereostructure, and biological activity

Toshiaki Teruya, Hiroaki Sasaki, Hidesuke Fukazawa, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

129 Citations (Scopus)

Abstract

A novel cytotoxic peptide, termed bisebromoamide (1), has been Isolated from the marine cyanobacterium Lyngbya sp. Its planar structure was determined by 1D and 2D NMR spectroscopy. The absolute stereostructure of 1 was determined by chemical degradation followed by chiral HPLC analysis. Bisebromoamide (1) exhibited potent protein kinase Inhibition: the phosphorylation of ERK In NRK cells by PDGFstimulation was selectively Inhibited by treatment with 10-0.1 μM of 1.

Original language	English
Pages (from-to)	5062-5065
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	21
DOIs	https://doi.org/10.1021/ol9020546
Publication status	Published - 2009 Nov 5

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol9020546

Cite this

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