Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS

Tomoo Osumi; Motohiro Kato; Meri Ouchi-Uchiyama; Daisuke Tomizawa; Keisuke Kataoka; Yoichi Fujii; Masafumi Seki; Junko Takita; Seishi Ogawa; Toru Uchiyama; Kentaro Ohki; Nobutaka Kiyokawa

doi:10.1002/pbc.26496

Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS

Tomoo Osumi, Motohiro Kato, Meri Ouchi-Uchiyama, Daisuke Tomizawa, Keisuke Kataoka, Yoichi Fujii, Masafumi Seki, Junko Takita, Seishi Ogawa, Toru Uchiyama, Kentaro Ohki, Nobutaka Kiyokawa

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.

Original language	English
Article number	e26496
Journal	Pediatric Blood and Cancer
Volume	64
Issue number	9
DOIs	https://doi.org/10.1002/pbc.26496
Publication status	Published - 2017 Sept
Externally published	Yes

Keywords

CNG
JMML
KRAS
blast crisis
duplication

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.26496

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title = "Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS",

abstract = "Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.",

keywords = "CNG, JMML, KRAS, blast crisis, duplication",

author = "Tomoo Osumi and Motohiro Kato and Meri Ouchi-Uchiyama and Daisuke Tomizawa and Keisuke Kataoka and Yoichi Fujii and Masafumi Seki and Junko Takita and Seishi Ogawa and Toru Uchiyama and Kentaro Ohki and Nobutaka Kiyokawa",

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T1 - Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS

AU - Osumi, Tomoo

AU - Kato, Motohiro

AU - Ouchi-Uchiyama, Meri

AU - Tomizawa, Daisuke

AU - Kataoka, Keisuke

AU - Fujii, Yoichi

AU - Seki, Masafumi

AU - Takita, Junko

AU - Ogawa, Seishi

AU - Uchiyama, Toru

AU - Ohki, Kentaro

AU - Kiyokawa, Nobutaka

PY - 2017/9

Y1 - 2017/9

N2 - Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.

AB - Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.

KW - CNG

KW - JMML

KW - KRAS

KW - blast crisis

KW - duplication

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JO - Pediatric Blood and Cancer

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Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS

Abstract

Keywords

ASJC Scopus subject areas

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