Blood-direct InvaderPlus® as a new method for genetic testing

Akira Hirasawa, Tomoko Akahane, Yusuke Tanigawara, Daisuke Aoki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aim: This study compared the efficiency of Blood-direct InvaderPlus® with existing methods for detecting genetic polymorphisms by using clinical samples, and to determine whether this new method can be used for future clinical studies. Materials & methods: We developed a new method, called Blood-direct InvaderPlus, for detecting genetic polymorphisms. Whole-blood samples were subjected to genetic analysis with the new method and also the conventional method. Results: The results obtained with the new method were consistent with those of direct sequencing. Blood-direct InvaderPlus was able to detect gene polymorphisms of UGT1A16,27,28,60, VKORC1 -1639G>A, VKORC1 1173T>C and CYP2C92 and3 much faster than the conventional methods. Conclusion: Blood-direct InvaderPlus allowed accurate, simple and rapid detection of genetic polymorphisms.

Original languageEnglish
Pages (from-to)657-663
Number of pages7
JournalPersonalized Medicine
Issue number6
Publication statusPublished - 2012 Aug
Externally publishedYes


  • CYP2C9
  • InvaderPlus®
  • UGT1A1
  • VKORC1
  • genetic testing
  • pharmacogenomics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology


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