Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement

Kenta Gonokami; Taku Obara; Mitsuru Kobayashi; Sakiko Katada; Azusa Hara; Hirohito Metoki; Kei Asayama; Masahiro Kikuya; Takayoshi Ohkubo; Yutaka Imai

doi:10.3109/10641960903443541

Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement

Kenta Gonokami, Taku Obara, Mitsuru Kobayashi, Sakiko Katada, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.

Original language	English
Pages (from-to)	311-317
Number of pages	7
Journal	Clinical and Experimental Hypertension
Volume	32
Issue number	5
DOIs	https://doi.org/10.3109/10641960903443541
Publication status	Published - 2010 Aug
Externally published	Yes

Keywords

Doxazosin
Home blood pressure (HBP)
Morning hypertension

ASJC Scopus subject areas

Internal Medicine
Physiology

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10.3109/10641960903443541

Cite this

@article{2445160524c8477b96738cd40c1be010,

title = "Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement",

abstract = "The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.",

keywords = "Doxazosin, Home blood pressure (HBP), Morning hypertension",

author = "Kenta Gonokami and Taku Obara and Mitsuru Kobayashi and Sakiko Katada and Azusa Hara and Hirohito Metoki and Kei Asayama and Masahiro Kikuya and Takayoshi Ohkubo and Yutaka Imai",

note = "Funding Information: This work was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology and grants from the National Cardiovascular Center in Japan.",

year = "2010",

month = aug,

doi = "10.3109/10641960903443541",

language = "English",

volume = "32",

pages = "311--317",

journal = "Clinical and Experimental Hypertension",

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T1 - Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement

AU - Gonokami, Kenta

AU - Obara, Taku

AU - Kobayashi, Mitsuru

AU - Katada, Sakiko

AU - Hara, Azusa

AU - Metoki, Hirohito

AU - Asayama, Kei

AU - Kikuya, Masahiro

AU - Ohkubo, Takayoshi

AU - Imai, Yutaka

N1 - Funding Information: This work was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology and grants from the National Cardiovascular Center in Japan.

PY - 2010/8

Y1 - 2010/8

N2 - The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.

AB - The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.

KW - Doxazosin

KW - Home blood pressure (HBP)

KW - Morning hypertension

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DO - 10.3109/10641960903443541

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SP - 311

EP - 317

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

IS - 5

ER -

Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement

Abstract

Keywords

ASJC Scopus subject areas

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