Brachial-ankle pulse wave velocity predicts silent cerebrovascular diseases in patients with end-stage renal diseases

Naoki Washida, Shu Wakino, Koichi Hayashi, Takashi Kuwahara, Hiroshi Itoh

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Aim: Cerebrovascular disease (CVD) is a major determinant of the prognosis in end-stage renal diseases (ESRD). The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD. Methods: CVD (lacunes and carotid/intracranial artery stenosis) was evaluated with brain magnetic resonance imaging (MRI), and carotid/intracranial artery magnetic resonance angiography (MRA) in 44 pre-dialytic patients. The severity of CVD was evaluated by the number of lacunes and the degree of stenosis, respectively. The association between CVD and atherosclerotic parameters was evaluated. Results: Patients with severe lacunes (n = 18) manifested older age, lower diastolic blood pressure, serum creatinine and albumin, and higher CRP and serum calcium than those with absent-moderate lacunes (n = 26). When assessed by multivariate analysis, only baPWV was adopted as an independent risk factor for severe lacunes. Furthermore, baPWV and i-PTH were associated with the severity of carotid/intracranial artery stenosis, both of which were independent of other risk factors, including age and diabetes. Conclusions: Arterial stiffness may constitute a novel determinant predicting the severity of CVD in pre-dialytic patients besides classical risk factors.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalJournal of atherosclerosis and thrombosis
Issue number2
Publication statusPublished - 2010
Externally publishedYes


  • Carotid/intracranial artery stenosis
  • End-stage renal disease
  • Lacunar infarction
  • Malnutrition-inflammation-atherosclerosis syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical


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