Brachytherapy for prostate cancer

Atsunori Yorozu, Kazuhito Toya, Toshio Ohashi, Kae Ohsuga, Reiko Ito, Tomotaka Kasamatsu, Shiro Saito, Tetsuo Momma

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


This review article aims to overview modern prostate brachytherapy in Japan. Permanent transperineal prostate brachytherapy with I-125 started in September, 2003 in Japan. Brachytherapy has several advantages: the dose is adapted precisely to the tumor shape and size, and the long-lived isotope gives a higher tumor dose with less damage to normal tissue; less-time consuming for patients and staff: long-term results comparable to surgery or external beam series in the USA; and quality of life after brachytherapy also appealing. These advantages have brought about increasing use in Japan as well. Patients with a high probability of organ-confined disease and a low-risk group are appropriately treated with brachytherapy. Brachytherapy candidates with a significant risk of extraprostatic extension should be treated with supplemental external beam radiation therapy. High-dose-rate (HDR) brachytherapy with Ir-192 has preceded seed implants in Japan. HDR has some theoretical advantages. Long-term results of brachytherapy in the USA are comparable with surgery or external beam irradiation so far. We should develop more sophisticated brachytherapy techniques in Japan.

Original languageEnglish
Pages (from-to)424-427
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number4
Publication statusPublished - 2006 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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