Brain uptake of halogenated products of D-glucal

Y. Homma; Y. Murase; M. Ishii

doi:10.1007/BF02517592

Brain uptake of halogenated products of D-glucal

Y. Homma, Y. Murase, M. Ishii

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Halogenated products of D-glucal were obtained on direct addition of halogens (³⁶Cl and⁸²Br) to D-glucal, which is a class of unsaturated sugar derivatives and had been synthesized from D-glucose. Brain uptake of the halogenated products was found to be greater than those of 2-deoxy-D-glucose and D-glucose. The halogenation reaction is sufficiently rapid and usable activity from D-glucal dihalides is twice as much as those from equal moles of¹⁸F-2-deoxy-2-fluoro-D-glucose and¹⁸F-3-deoxy-3-fluoro-D-glucose. D-Glucal can be readily available for months without any detectable chemical alteration.

Original language	English
Pages (from-to)	283-288
Number of pages	6
Journal	Journal of Radioanalytical Chemistry
Volume	76
Issue number	2
DOIs	https://doi.org/10.1007/BF02517592
Publication status	Published - 1983 Sept

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging

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title = "Brain uptake of halogenated products of D-glucal",

abstract = "Halogenated products of D-glucal were obtained on direct addition of halogens (36Cl and82Br) to D-glucal, which is a class of unsaturated sugar derivatives and had been synthesized from D-glucose. Brain uptake of the halogenated products was found to be greater than those of 2-deoxy-D-glucose and D-glucose. The halogenation reaction is sufficiently rapid and usable activity from D-glucal dihalides is twice as much as those from equal moles of18F-2-deoxy-2-fluoro-D-glucose and18F-3-deoxy-3-fluoro-D-glucose. D-Glucal can be readily available for months without any detectable chemical alteration.",

author = "Y. Homma and Y. Murase and M. Ishii",

year = "1983",

month = sep,

doi = "10.1007/BF02517592",

language = "English",

volume = "76",

pages = "283--288",

journal = "Journal of Radioanalytical Chemistry",

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T1 - Brain uptake of halogenated products of D-glucal

AU - Homma, Y.

AU - Murase, Y.

AU - Ishii, M.

PY - 1983/9

Y1 - 1983/9

N2 - Halogenated products of D-glucal were obtained on direct addition of halogens (36Cl and82Br) to D-glucal, which is a class of unsaturated sugar derivatives and had been synthesized from D-glucose. Brain uptake of the halogenated products was found to be greater than those of 2-deoxy-D-glucose and D-glucose. The halogenation reaction is sufficiently rapid and usable activity from D-glucal dihalides is twice as much as those from equal moles of18F-2-deoxy-2-fluoro-D-glucose and18F-3-deoxy-3-fluoro-D-glucose. D-Glucal can be readily available for months without any detectable chemical alteration.

AB - Halogenated products of D-glucal were obtained on direct addition of halogens (36Cl and82Br) to D-glucal, which is a class of unsaturated sugar derivatives and had been synthesized from D-glucose. Brain uptake of the halogenated products was found to be greater than those of 2-deoxy-D-glucose and D-glucose. The halogenation reaction is sufficiently rapid and usable activity from D-glucal dihalides is twice as much as those from equal moles of18F-2-deoxy-2-fluoro-D-glucose and18F-3-deoxy-3-fluoro-D-glucose. D-Glucal can be readily available for months without any detectable chemical alteration.

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ER -

Brain uptake of halogenated products of D-glucal

Abstract

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