Breast cancer

Tadashi Ikeda, Hiromitsu Jinno, Akira Matsui, Yoko Mitsui, Sota Asaga, Takeshi Muto, Masahiro Wada, Masaki Kitajima

Research output: Contribution to journalReview articlepeer-review


Adjuvant chemo-endocrine therapy for breast cancer (ACETBC) trial has been the first large scaled clinical trial performed in Japan. Several prospective randomized trials have been performed in Japan since ACETBC-1 trial started in 1985. The effect of oral 5-FU agents had been tested in prospective randomized trials and the statistically marginal effect of oral 5-FU agents in adjuvant settings has been reported. Several trials having CMF as a control arm started in 1996 when CMF combination chemotherapy was approved by the government. The results of these trials have not been published. To perform good clinical trials, it is imperative to construct infrastructures including clinical research coordinator, and abolish governmental regulation of the dose of anticancer agents.

Original languageEnglish
Pages (from-to)1509-1515
Number of pages7
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number9
Publication statusPublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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