Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine

Dong Nyoung Heo, Dae Hyeok Yang, Jung Bok Lee, Min Soo Bae, Jung Ho Kim, Seong Hwan Moon, Heoung Jae Chun, Chun Ho Kim, Ho Nam Lim, Il Keun Kwon

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)


Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was comixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds.

Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalJournal of Biomedical Nanotechnology
Issue number3
Publication statusPublished - 2013 Mar
Externally publishedYes


  • Burn Wound Healing
  • Electrospinning
  • PU/Gelatin Nanofiber Scaffold
  • Silver-Sulfadiazine

ASJC Scopus subject areas

  • General Medicine


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