Cancer immunotherapy by immuno-checkpoint blockade

Yutaka Kawakami

Research output: Contribution to journalArticlepeer-review


As cancer immunotherapies utilizing anti-tumor T-cell responses, immuno-checkpoint blockade and adoptive T-cell immunotherapy have recently achieved durable responses even in advanced cancer patients with metastases. Administration of antibodies on the T-cell surface, CTLA-4 and PD-1 (or PD-1 ligand PD-L1), resulted in tumor regression of not only melanoma and renal cell cancer which were known to be relatively sensitive to immunotherapy, but also various malignancies including lung, bladder, ovarian, gastric, and head and neck cancers, as well as hematological malignancies such as Hodgkin and B-cell malignant lymphomas. These findings have changed the status of immunotherapy in the development of cancer treatments. Currently, development of combinations employing cancer immunotherapy with immuno-checkpoint blockade, as well as personalized cancer immunotherapy based on the evaluation of pretreatment immune status, are in progress.

Original languageEnglish
Pages (from-to)2186-2194
Number of pages9
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Issue number10
Publication statusPublished - 2015 Oct 1

ASJC Scopus subject areas

  • Medicine(all)


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