Candida albicans infection delays duodenal ulcer healing in cysteamine-induced duodenal ulcers in rats

Longxue Jin, Masashi Yoshida, Tetsuya Nakamura, Hideki Ishikawa, Go Wakabayashi, Minoru Tanabe, Shigeyuki Kawachi, Masahiro Shinoda, Yoshirou Saikawa, Norihito Wada, Kaori Kameyama, Koichiro Kumai, Tetsuro Kubota, Katsuko Sano, Keisuke Nagao, Masayuki Amagai, Yuko Kitagawa, Masaki Kitajima

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A low curability of ulcers infected with Candida has been reported in the literature. The aim of the study reported here was to investigate experimentally whether Candida infection affects the healing of ulcers. Candida albicans (the Candida group) or saline (the control group) was administered intragastrically into rats with a cysteamine-induced duodenal ulcer. The duodenal lesions, vascular endothelial growth factor A (VEGF-A) and proliferating cell nuclear antigen (PCNA) were assessed. On Day 7 post-administration, 70.4% rats of the Candida group had a duodenal ulcer compared with 33.3% in the control group (P < 0.05). The duodenal ulcer in the Candida group was significantly larger and deeper than that in the control group. The number of VEGF-A- and PCNA-positive cells was smaller and the area of VEGF-A expression was lower in the Candida group. Using a rat model, we have demonstrated that Candida infection can delay the wound healing process of duodenal ulcers by means of a low expression of VEGF-A and PCNA.

Original languageEnglish
Pages (from-to)2878-2885
Number of pages8
JournalDigestive Diseases and Sciences
Issue number11
Publication statusPublished - 2008 Nov


  • Cysteamine
  • Gastrointestinal diseases
  • Peptic ulcer
  • Proliferating cell nuclear antigen
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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