TY - JOUR
T1 - Candida albicans infection delays duodenal ulcer healing in cysteamine-induced duodenal ulcers in rats
AU - Jin, Longxue
AU - Yoshida, Masashi
AU - Nakamura, Tetsuya
AU - Ishikawa, Hideki
AU - Wakabayashi, Go
AU - Tanabe, Minoru
AU - Kawachi, Shigeyuki
AU - Shinoda, Masahiro
AU - Saikawa, Yoshirou
AU - Wada, Norihito
AU - Kameyama, Kaori
AU - Kumai, Koichiro
AU - Kubota, Tetsuro
AU - Sano, Katsuko
AU - Nagao, Keisuke
AU - Amagai, Masayuki
AU - Kitagawa, Yuko
AU - Kitajima, Masaki
PY - 2008/11
Y1 - 2008/11
N2 - A low curability of ulcers infected with Candida has been reported in the literature. The aim of the study reported here was to investigate experimentally whether Candida infection affects the healing of ulcers. Candida albicans (the Candida group) or saline (the control group) was administered intragastrically into rats with a cysteamine-induced duodenal ulcer. The duodenal lesions, vascular endothelial growth factor A (VEGF-A) and proliferating cell nuclear antigen (PCNA) were assessed. On Day 7 post-administration, 70.4% rats of the Candida group had a duodenal ulcer compared with 33.3% in the control group (P < 0.05). The duodenal ulcer in the Candida group was significantly larger and deeper than that in the control group. The number of VEGF-A- and PCNA-positive cells was smaller and the area of VEGF-A expression was lower in the Candida group. Using a rat model, we have demonstrated that Candida infection can delay the wound healing process of duodenal ulcers by means of a low expression of VEGF-A and PCNA.
AB - A low curability of ulcers infected with Candida has been reported in the literature. The aim of the study reported here was to investigate experimentally whether Candida infection affects the healing of ulcers. Candida albicans (the Candida group) or saline (the control group) was administered intragastrically into rats with a cysteamine-induced duodenal ulcer. The duodenal lesions, vascular endothelial growth factor A (VEGF-A) and proliferating cell nuclear antigen (PCNA) were assessed. On Day 7 post-administration, 70.4% rats of the Candida group had a duodenal ulcer compared with 33.3% in the control group (P < 0.05). The duodenal ulcer in the Candida group was significantly larger and deeper than that in the control group. The number of VEGF-A- and PCNA-positive cells was smaller and the area of VEGF-A expression was lower in the Candida group. Using a rat model, we have demonstrated that Candida infection can delay the wound healing process of duodenal ulcers by means of a low expression of VEGF-A and PCNA.
KW - Cysteamine
KW - Gastrointestinal diseases
KW - Peptic ulcer
KW - Proliferating cell nuclear antigen
KW - Vascular endothelial growth factor
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UR - http://www.scopus.com/inward/citedby.url?scp=53849120191&partnerID=8YFLogxK
U2 - 10.1007/s10620-008-0385-9
DO - 10.1007/s10620-008-0385-9
M3 - Article
C2 - 18622701
AN - SCOPUS:53849120191
SN - 0163-2116
VL - 53
SP - 2878
EP - 2885
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 11
ER -