Carbon-ion radiation therapy for prostate cancer

Hitoshi Ishikawa, Hiroshi Tsuji, Tadashi Kamada, Koichiro Akakura, Hiroyoshi Suzuki, Jun Shimazaki, Hirohiko Tsujii, Jun Shimazaki, Koichiro Akakura, Tetsuo Akimoto, Tomohiko Ichikawa, Tatsuo Igarashi, Koji Kawamura, Takeshi Ueda, Mototsugu Oya, Hideyuki Sakurai, Mizuki Onozawa, Chihiro Kanehira, Koichi Kamura, Hiroyoshi SuzukiKazumasa Nakamura, Masaoki Harada, Makoto Fujime, Ken Marumo, Hirohiko Tsujii, Tadashi Kamada, Hiroshi Tsuji

Research output: Contribution to journalReview articlepeer-review

84 Citations (Scopus)


In 1994, carbon-ion radiotherapy was started at the National Institute of Radiological Sciences using the Heavy-Ion Medical Accelerator in Chiba. Between June 1995 and March 2000, two phaseI/II dose escalation studies (protocols 9402 and 9703) of hypofractionated carbon-ion radiotherapy for both early- and advance-stage prostate cancer patients had been carried out to establish radiotherapy technique and to determine the optimal radiation dose. To validate the feasibility and efficacy of hypofractionated carbon-ion radiotherapy, a phaseII study (9904) was initiated in April 2000 using the shrinking field technique and the recommended dose fractionation (66 gray equivalents in 20 fractions over 5weeks) obtained from the phaseI/II studies, and was successfully completed in October 2003. The data from 175 patients in the phaseII study showed the importance of an appropriate use of androgen deprivation therapy according to tumor risk group. Since November 2003, carbon-ion radiotherapy for prostate cancer was approved as "Highly Advanced Medical Technology" from the Ministry of Health, Labor, and Welfare, and since then approximately 1100 patients have received carbon-ion radiotherapy as of July 2011. In this review, we introduce our steps thorough three clinical trials carried out at National Institute of Radiological Sciences, and show the updated data of carbon-ion radiotherapy obtained from approximately 1000 prostate cancer patients. In addition, our recent challenge and future direction will be also described.

Original languageEnglish
Pages (from-to)296-305
Number of pages10
JournalInternational Journal of Urology
Issue number4
Publication statusPublished - 2012 Apr


  • Androgen deprivation therapy
  • Carbon-ion radiation therapy
  • Hypofractionation
  • Prostate cancer
  • Survival

ASJC Scopus subject areas

  • Urology


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