Carbon monoxide as an endogenous modulator of hepatic vascular perfusion

Makoto Suematsu, Satoshi Kashiwagi, Tsuyoshi Sano, Nobuhito Goda, Yuichi Shinoda, Yuzuru Ishimura

Research output: Contribution to journalArticlepeer-review

142 Citations (Scopus)


Carbon monoxide (CO) generated by heme oxygenase has recently been considered a neural messenger in brain. This observation prompted us to investigate whether CO participates in vascular regulation in the liver, another organ with high levels of heme oxygenase activity. In isolated perfused rat liver, submicromolar levels of CO were detectable in the effluent and were able to be suppressed by the administration of Zn protoporphyrin IX (1 μM), a potent inhibitor of heme oxygenase. Furthermore, zinc protoporphyrin IX (1 μM) promoted an increase in the perfusion pressure under the constant flow conditions. These changes were reversed by adding CO (2 μM) or a cGMP analogue 8-bromo-cGMP (1 μM) in the perfusate. The present findings indicate that CO can function as an endogenous modulator of vascular perfusion in the liver.

Original languageEnglish
Pages (from-to)1333-1337
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 1994 Dec 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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