TY - JOUR
T1 - Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
AU - Shimoda, Masayuki
AU - Mellody, Kieran T.
AU - Orimo, Akira
N1 - Funding Information:
This work was supported by Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research (M.S.) and Cancer Research UK (CR-UK) grant number C147/A6058 (A.O.).
PY - 2010/2
Y1 - 2010/2
N2 - Tumours are highly complex tissues composed of carcinoma cells and surrounding stroma, which is constructed by various different types of mesenchymal cells and an extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which consist of both fibroblasts and myofibroblasts, are frequently observed in the stroma of human carcinomas, and their presence in large numbers is often associated with the development of high-grade malignancies and poor prognoses. Moreover, in human tumour xenograft models, CAFs extracted from the tumour are more capable of promoting tumour growth through their interactions with carcinoma cells when compared to those isolated from non-cancerous stroma. Taken together, these observations strongly suggest that CAFs actively contribute to tumour progression. In this review we highlight the emerging roles of these cells in promoting tumourigenesis, and we discuss the molecular mechanisms underlying their tumour-promoting capabilities and their cellular origin.
AB - Tumours are highly complex tissues composed of carcinoma cells and surrounding stroma, which is constructed by various different types of mesenchymal cells and an extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which consist of both fibroblasts and myofibroblasts, are frequently observed in the stroma of human carcinomas, and their presence in large numbers is often associated with the development of high-grade malignancies and poor prognoses. Moreover, in human tumour xenograft models, CAFs extracted from the tumour are more capable of promoting tumour growth through their interactions with carcinoma cells when compared to those isolated from non-cancerous stroma. Taken together, these observations strongly suggest that CAFs actively contribute to tumour progression. In this review we highlight the emerging roles of these cells in promoting tumourigenesis, and we discuss the molecular mechanisms underlying their tumour-promoting capabilities and their cellular origin.
KW - Carcinoma-associated fibroblasts (CAFs)
KW - Fibrosis
KW - SDF-1
KW - Stromal myofibroblasts
KW - TGF-β
KW - Wound healing
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U2 - 10.1016/j.semcdb.2009.10.002
DO - 10.1016/j.semcdb.2009.10.002
M3 - Review article
C2 - 19857592
AN - SCOPUS:75849159205
SN - 1084-9521
VL - 21
SP - 19
EP - 25
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
IS - 1
ER -
