Cardiac sarcoma showing bone formation and neurogenic markers: Report of a case

H. Okita, T. Hirotani, H. Kodama, H. Orikasa, B. P. Eyden, K. Yamazaki

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A 54 year-old Japanese female with cardiac insufficiency was found to have a left atrial mass and smaller masses on the mitral valve. Excisional surgery of the masses and mitral valve replacement were carried out. In spite of intensive post-operative radiation therapy, the patient died of intra-atrial recurrence and brain metastases after 8 months. Tumour cells were spindled to oval, were positive for vimentin, S100 protein and neurone specific enolase. Laminin and fibronectin were also demonstrated. Bone formation and myxoid areas were present. An ultrastructurally identifiable stromal component, possibly responsible for laminin and fibronectin staining, was also present. The merits of the two main diagnostic possibilities - a mesenchymal/fibroblastic sarcoma showing bone and aberrant S100 protein, and a malignant peripheral nerve sheath tumour with bone - were discussed. In practical terms, the tumour was given the diagnosis of unclassifiable sarcoma of the left atrium. Atrial sarcomas showing neural markers and bone formation are exceedingly rare, and this report adds a further exceptionally uncommon case to the literature.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of submicroscopic cytology and pathology
Issue number1
Publication statusPublished - 2002 Jan


  • Atrium
  • Brain metastasis
  • Electron microscope
  • Laminin
  • Myxosarcoma
  • Sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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