Cartridge Device Capable of Spontaneous Solution Exchange for Sensor Cell Production

Aoi Tanaka, Sho Takamori, Hisatoshi Mimura, Toshihisa Osaki, Norihisa Miki, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports a cartridge-type device to produce sensor cells with spontaneous solution exchange. Our group has developed a cell-based odorant sensor expressed olfactory receptors. These sensor cells presented excellent sensitivity and specificity, which would be useful for a wide range of sensor applications. However, production of such sensor cells requires multiple times of aseptic solution exchanges. In this work, we develop a cartridge-type cell culture device that utilizes capillary force for spontaneous solution exchange without pumps or tubes. When the cartridge is set to the exchange stage, the specified volume of solution is exchanged immediately. We experimentally examine the solution exchange, and demonstrate the response of a sensor cell to a chemical stimulus in the exchanged solution. We consider that the device would be useful to produce multiple types of sensor cells.

Original languageEnglish
Title of host publication35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages166-167
Number of pages2
ISBN (Electronic)9781665409117
DOIs
Publication statusPublished - 2022
Event35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 - Tokyo, Japan
Duration: 2022 Jan 92022 Jan 13

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2022-January
ISSN (Print)1084-6999

Conference

Conference35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
Country/TerritoryJapan
CityTokyo
Period22/1/922/1/13

Keywords

  • Biohybrid odorant sensor
  • Capillary force
  • Insect olfactory receptor
  • Sensor cell
  • Solution exchange

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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