Catalytic asymmetric hydrophosphonylation of ketimines

Liang Yin, Youmei Bao, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Catalytic asymmetric hydrophosphonylation of aromatic and aliphatic N-thiophosphinoyl ketimines with dialkyl phosphite was efficiently promoted by as little as 0.5 mol% of catalyst loading at ambient temperature. The catalyst can be recovered for repeated use, and facile removal of the thiophosphinoyl group allowed for ready access to the phosphonic acid analogue of enantioenriched α,α-disubstituted α-amino acids.

Original languageEnglish
Pages (from-to)10338-10341
Number of pages4
JournalJournal of the American Chemical Society
Issue number28
Publication statusPublished - 2013 Jul 17
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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