Catalytic enantioselective borohydride reduction of Ortho-fluorinated benzophenones

Ai Kokura; Saiko Tanaka; Taketo Ikeno; Tohru Yamada

doi:10.1021/ol060927p

Catalytic enantioselective borohydride reduction of Ortho-fluorinated benzophenones

Ai Kokura, Saiko Tanaka, Taketo Ikeno, Tohru Yamada

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

In the presence of the optically active ketoiminatocobalt(II) complexes, the enantioselective borohydride reduction of benzophenones was successfully completed. The fluorine atom on the ortho position of the benzophenone and aryl ketones proved effective for obtaining high enantioselectivities. The combined use of modified lithium borohydride afforded the corresponding benzhydrols and arylcarbinols in high yield and high enantioselectivity (88-96% ee).

Original language	English
Pages (from-to)	3025-3027
Number of pages	3
Journal	Organic Letters
Volume	8
Issue number	14
DOIs	https://doi.org/10.1021/ol060927p
Publication status	Published - 2006 Jul 6

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol060927p

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abstract = "In the presence of the optically active ketoiminatocobalt(II) complexes, the enantioselective borohydride reduction of benzophenones was successfully completed. The fluorine atom on the ortho position of the benzophenone and aryl ketones proved effective for obtaining high enantioselectivities. The combined use of modified lithium borohydride afforded the corresponding benzhydrols and arylcarbinols in high yield and high enantioselectivity (88-96% ee).",

author = "Ai Kokura and Saiko Tanaka and Taketo Ikeno and Tohru Yamada",

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AU - Kokura, Ai

AU - Tanaka, Saiko

AU - Ikeno, Taketo

AU - Yamada, Tohru

PY - 2006/7/6

Y1 - 2006/7/6

N2 - In the presence of the optically active ketoiminatocobalt(II) complexes, the enantioselective borohydride reduction of benzophenones was successfully completed. The fluorine atom on the ortho position of the benzophenone and aryl ketones proved effective for obtaining high enantioselectivities. The combined use of modified lithium borohydride afforded the corresponding benzhydrols and arylcarbinols in high yield and high enantioselectivity (88-96% ee).

AB - In the presence of the optically active ketoiminatocobalt(II) complexes, the enantioselective borohydride reduction of benzophenones was successfully completed. The fluorine atom on the ortho position of the benzophenone and aryl ketones proved effective for obtaining high enantioselectivities. The combined use of modified lithium borohydride afforded the corresponding benzhydrols and arylcarbinols in high yield and high enantioselectivity (88-96% ee).

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Catalytic enantioselective borohydride reduction of Ortho-fluorinated benzophenones

Abstract

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