Catalytic Methods for C-H Bond Functionalization: Application in Organic Synthesis

Fumitoshi Kakiuchi, Naoto Chatani

Research output: Contribution to journalReview articlepeer-review

1041 Citations (Scopus)


The development of catalytic reactions involving carbon-hydrogen bond cleavage is currently one of the most attractive research subjects in organic and organometallic chemistry. About 40 years have past since the pioneering report of the cleavage of C-H bonds with transition metal complexes. Since that time, a vast number of studies of the cleavage of C-H bonds, using stoichiometric amounts of transition metal complexes has appeared. In the last decade, a variety of catalytic reactions involving C-H bond cleavage has been reported. In this review we briefly survey the results of these research activities with respect to the catalytic use of unreactive C-H bonds in organic synthesis.

Original languageEnglish
Pages (from-to)1077-1101
Number of pages25
JournalAdvanced Synthesis and Catalysis
Issue number9-10
Publication statusPublished - 2003 Sept
Externally publishedYes


  • Alkenylation
  • Alkylation
  • Borylation
  • C-C bond formation
  • C-H activation
  • Carbonylation
  • Silylation
  • Transition metal catalysts

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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