TY - JOUR
T1 - Catalytic nucleophilic activation of acetonitrile via a cooperative catalysis of cationic Ru complex, DBU, and NaPF6
AU - Kumagai, Naoya
AU - Matsunaga, Shigeki
AU - Shibasaki, Masakatsu
PY - 2007/8/27
Y1 - 2007/8/27
N2 - The development of an efficient catalytic system for the direct addition of acetonitrile under mild amine basic conditions is described. A cooperative catalysis of CpRu complex, DBU, and NaPF6 enables chemoselective and catalytic generation of nucleophiles from barely acidic acetonitrile, which is integrated into the addition to aldehydes, imines, and activated ketones. Mechanistic investigations revealed that the three catalyst components work together to achieve high catalytic efficiency.
AB - The development of an efficient catalytic system for the direct addition of acetonitrile under mild amine basic conditions is described. A cooperative catalysis of CpRu complex, DBU, and NaPF6 enables chemoselective and catalytic generation of nucleophiles from barely acidic acetonitrile, which is integrated into the addition to aldehydes, imines, and activated ketones. Mechanistic investigations revealed that the three catalyst components work together to achieve high catalytic efficiency.
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U2 - 10.1016/j.tet.2007.04.051
DO - 10.1016/j.tet.2007.04.051
M3 - Article
AN - SCOPUS:34447513871
SN - 0040-4020
VL - 63
SP - 8598
EP - 8608
JO - Tetrahedron
JF - Tetrahedron
IS - 35
ER -