Catalytic silylation of secondary alcohols by pyridine N-oxide derivative

Keisuke Yoshida, Ken Ichi Takao

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


The reaction of t-butyldiphenylsilyl (TBDPS) chloride with secondary alcohols was catalyzed by pyrrolidinopyridine N-oxide (PPYO) in the presence of diisopropylethylamine (DIPEA) at room temperature, giving the corresponding TBDPS ethers in high yields.

Original languageEnglish
Pages (from-to)6861-6863
Number of pages3
JournalTetrahedron Letters
Issue number50
Publication statusPublished - 2014 Dec 10


  • Organocatalyst
  • Pyridine N-oxide
  • Secondary alcohols
  • Silylation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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