TY - GEN
T1 - CATHETER DELIVERY OF RADIOPAQUE CELL-ENCAPSULATED HYDROGEL MICROFIBERS FOR CELL THERAPY
AU - Takakura, Naoki
AU - Ohta, Hiroki
AU - Komatsu, Teppei
AU - Kurashina, Yuta
AU - Okano, Hirotaka J.
AU - Onoe, Hiroaki
N1 - Funding Information:
This work was supported by the Translational Research program; Strategic Promotion for practical application of Innovative medical Technology of the Japan Agency for Medical Research and Development.
Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - This paper proposes a cell-encapsulated core-shell radiopaque hydrogel microfiber for in vivo cell therapy. The microfiber is composed of barium alginate gel containing zirconia particles in the shell and collagen gel encapsulating mesenchymal stem cells in the core. We confirmed that the cells in the fiber secrete paracrine factors to the outside of the fiber. Moreover, we demonstrated the improvement of the renal function of the rats by delivering the fiber into renal arteries. We believe that our fiber would treat incurable diseases including tissue degeneration.
AB - This paper proposes a cell-encapsulated core-shell radiopaque hydrogel microfiber for in vivo cell therapy. The microfiber is composed of barium alginate gel containing zirconia particles in the shell and collagen gel encapsulating mesenchymal stem cells in the core. We confirmed that the cells in the fiber secrete paracrine factors to the outside of the fiber. Moreover, we demonstrated the improvement of the renal function of the rats by delivering the fiber into renal arteries. We believe that our fiber would treat incurable diseases including tissue degeneration.
KW - barium alginate hydrogel
KW - catheter
KW - cell therapy
KW - mesenchymal stem cell
KW - microfiber
UR - http://www.scopus.com/inward/record.url?scp=85136911917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85136911917&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85136911917
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 109
EP - 110
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -