Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons

Sonja Rakić; Shigeaki Kanatani; David Hunt; Clare Faux; Anna Cariboni; Francesca Chiara; Shabana Khan; Olivia Wansbury; Beatrice Howard; Kazunori Nakajima; Margareta Nikolić; John G. Parnavelas

doi:10.1093/cercor/bht290

Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons

Sonja Rakić, Shigeaki Kanatani, David Hunt, Clare Faux, Anna Cariboni, Francesca Chiara, Shabana Khan, Olivia Wansbury, Beatrice Howard, Kazunori Nakajima, Margareta Nikolić, John G. Parnavelas

Department of Anatomy

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Interneuron dysfunction in humans is often associated with neurological and psychiatric disorders, such as epilepsy, schizophrenia, and autism. Some of these disorders are believed to emerge during brain formation, at the time of interneuron specification, migration, and synapse formation. Here, using a mouse model and a host of histological and molecular biological techniques, we report that the signaling molecule cyclin-dependent kinase 5 (Cdk5), and its activator p35, control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelopmental signaling pathway, ErbB4/phosphatidylinositol 3-kinase, that has been repeatedly linked to schizophrenia. This finding identifies Cdk5 as a crucial signaling factor in cortical interneuron development in mammals.

Original language	English
Pages (from-to)	991-1003
Number of pages	13
Journal	Cerebral Cortex
Volume	25
Issue number	4
DOIs	https://doi.org/10.1093/cercor/bht290
Publication status	Published - 2015 Apr 1

Keywords

cerebral cortex
interneurons
migration
mouse
phosphorylation

ASJC Scopus subject areas

Cognitive Neuroscience
Cellular and Molecular Neuroscience

Access to Document

10.1093/cercor/bht290

Cite this

@article{22cc6699088f4c5f86d4b0f68bd83ae3,

title = "Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons",

abstract = "Interneuron dysfunction in humans is often associated with neurological and psychiatric disorders, such as epilepsy, schizophrenia, and autism. Some of these disorders are believed to emerge during brain formation, at the time of interneuron specification, migration, and synapse formation. Here, using a mouse model and a host of histological and molecular biological techniques, we report that the signaling molecule cyclin-dependent kinase 5 (Cdk5), and its activator p35, control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelopmental signaling pathway, ErbB4/phosphatidylinositol 3-kinase, that has been repeatedly linked to schizophrenia. This finding identifies Cdk5 as a crucial signaling factor in cortical interneuron development in mammals.",

keywords = "cerebral cortex, interneurons, migration, mouse, phosphorylation",

author = "Sonja Raki{\'c} and Shigeaki Kanatani and David Hunt and Clare Faux and Anna Cariboni and Francesca Chiara and Shabana Khan and Olivia Wansbury and Beatrice Howard and Kazunori Nakajima and Margareta Nikoli{\'c} and Parnavelas, {John G.}",

note = "Funding Information: This work was supported by Wellcome Trust (grant numbers 074549 and 089775; J.G.P.), the Strategic Research Program for Brain Sciences (“Understanding of molecular and environmental bases for brain health”; K.N.), the Grant-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science, and Technology of Japan (K.N.) and grants from Breakthrough Breast Cancer (B.H.). Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust. Publisher Copyright: {\textcopyright} The Author 2013. Published by Oxford University Press.",

year = "2015",

month = apr,

day = "1",

doi = "10.1093/cercor/bht290",

language = "English",

volume = "25",

pages = "991--1003",

journal = "Cerebral Cortex",

issn = "1047-3211",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons

AU - Rakić, Sonja

AU - Kanatani, Shigeaki

AU - Hunt, David

AU - Faux, Clare

AU - Cariboni, Anna

AU - Chiara, Francesca

AU - Khan, Shabana

AU - Wansbury, Olivia

AU - Howard, Beatrice

AU - Nakajima, Kazunori

AU - Nikolić, Margareta

AU - Parnavelas, John G.

N1 - Funding Information: This work was supported by Wellcome Trust (grant numbers 074549 and 089775; J.G.P.), the Strategic Research Program for Brain Sciences (“Understanding of molecular and environmental bases for brain health”; K.N.), the Grant-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science, and Technology of Japan (K.N.) and grants from Breakthrough Breast Cancer (B.H.). Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust. Publisher Copyright: © The Author 2013. Published by Oxford University Press.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Interneuron dysfunction in humans is often associated with neurological and psychiatric disorders, such as epilepsy, schizophrenia, and autism. Some of these disorders are believed to emerge during brain formation, at the time of interneuron specification, migration, and synapse formation. Here, using a mouse model and a host of histological and molecular biological techniques, we report that the signaling molecule cyclin-dependent kinase 5 (Cdk5), and its activator p35, control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelopmental signaling pathway, ErbB4/phosphatidylinositol 3-kinase, that has been repeatedly linked to schizophrenia. This finding identifies Cdk5 as a crucial signaling factor in cortical interneuron development in mammals.

AB - Interneuron dysfunction in humans is often associated with neurological and psychiatric disorders, such as epilepsy, schizophrenia, and autism. Some of these disorders are believed to emerge during brain formation, at the time of interneuron specification, migration, and synapse formation. Here, using a mouse model and a host of histological and molecular biological techniques, we report that the signaling molecule cyclin-dependent kinase 5 (Cdk5), and its activator p35, control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelopmental signaling pathway, ErbB4/phosphatidylinositol 3-kinase, that has been repeatedly linked to schizophrenia. This finding identifies Cdk5 as a crucial signaling factor in cortical interneuron development in mammals.

KW - cerebral cortex

KW - interneurons

KW - migration

KW - mouse

KW - phosphorylation

UR - http://www.scopus.com/inward/record.url?scp=84926681359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926681359&partnerID=8YFLogxK

U2 - 10.1093/cercor/bht290

DO - 10.1093/cercor/bht290

M3 - Article

C2 - 24142862

AN - SCOPUS:84926681359

SN - 1047-3211

VL - 25

SP - 991

EP - 1003

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 4

ER -

Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this