Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity

Hiroshi Sakamoto, Xiu Qin Zhang, Souichi Suenobu, Kazuyuki Ohbo, Minetaro Ogawa, Toshio Suda

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Cell to cell interaction in bone marrow is crucial for differentiation of hematopoietic cells. We have shown that EphB4 receptor is expressed in erythroid progenitor and its activation accelerates erythroid differentiation. To elucidate the role of EphB4 activation in erythropoiesis, we analyzed effects of EphB4 on cell adhesive pathways. Cell adhesion with the extension of filopodial pseudopod was observed by EphB4 activation. EphB4 activation also enhanced an effect of fibronectin-mediated adhesive pathway along with formation of the c-Cbl/CrkL complex. The tyrosine kinase activity of EphB4 was dispensable for those phenomena. These results suggest that activation of EphB4 participates in adhesive but not repulsive signals independently of its tyrosine kinase activity in hematopoietic cells.

Original languageEnglish
Pages (from-to)681-687
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 2004 Aug 27
Externally publishedYes


  • Adhesion
  • CrkL
  • EphB4
  • Fibronectin
  • c-Cbl

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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