Cell Death: Its Style and Significance

Hideyuki Saya

Research output: Chapter in Book/Report/Conference proceedingChapter


Natural selection is the mechanism of evolution originally proposed by Charles Darwin. This process is driven by mutation and death. Therefore, "individual death" is a critical event for evolution of species. Analogous to the significance of individual death in species evolution, recent biological observations have revealed that "cell death" is an important event for maintenance of individuals and offspring. Cell death is caused not only by injuries and pathological conditions, but also by programed intracellular signals. This type of programed cell death is called "apoptosis." Apoptosis signals are regulated in mitochondria, eukaryotic organelles of symbiotic origin, and play a critical role in survival of individuals by eliminating some cells.

Original languageEnglish
Title of host publicationTaking Life and Death Seriously - Bioethics from Japan
EditorsTakao Takahashi
Number of pages15
Publication statusPublished - 2005
Externally publishedYes

Publication series

NameAdvances in Bioethics
ISSN (Print)1479-3709

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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