Cell signaling: IP3 receptor types 2 and 3 mediates exocrine secretion underlying energy metabolism

Akira Futatsugi; Takeshi Nakamura; Maki K. Yamada; Etsuko Ebisui; Kyoko Nakamura; Kelko Uchida; Tetsuya Kitaguchi; Hiromi Takashi-Iwanaga; Tetsuo Noda; Jun Aruga; Katsuhiko Mikoshiba

doi:10.1126/science.1114110

Cell signaling: IP₃ receptor types 2 and 3 mediates exocrine secretion underlying energy metabolism

Akira Futatsugi, Takeshi Nakamura, Maki K. Yamada, Etsuko Ebisui, Kyoko Nakamura, Kelko Uchida, Tetsuya Kitaguchi, Hiromi Takashi-Iwanaga, Tetsuo Noda, Jun Aruga, Katsuhiko Mikoshiba

Research output: Contribution to journal › Article › peer-review

261 Citations (Scopus)

Abstract

Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP₃R2 and IP₃RB) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP ₃R2 and IP₃R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP₃R2 and IP₃R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.

Original language	English
Pages (from-to)	2232-2234
Number of pages	3
Journal	Science
Volume	309
Issue number	5744
DOIs	https://doi.org/10.1126/science.1114110
Publication status	Published - 2005 Sept 30
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1114110

Cite this

@article{39800141ffda43d6a518d3bd03234f6a,

title = "Cell signaling: IP3 receptor types 2 and 3 mediates exocrine secretion underlying energy metabolism",

abstract = "Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3RB) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP 3R2 and IP3R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.",

author = "Akira Futatsugi and Takeshi Nakamura and Yamada, {Maki K.} and Etsuko Ebisui and Kyoko Nakamura and Kelko Uchida and Tetsuya Kitaguchi and Hiromi Takashi-Iwanaga and Tetsuo Noda and Jun Aruga and Katsuhiko Mikoshiba",

year = "2005",

month = sep,

day = "30",

doi = "10.1126/science.1114110",

language = "English",

volume = "309",

pages = "2232--2234",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5744",

}

TY - JOUR

T1 - Cell signaling

T2 - IP3 receptor types 2 and 3 mediates exocrine secretion underlying energy metabolism

AU - Futatsugi, Akira

AU - Nakamura, Takeshi

AU - Yamada, Maki K.

AU - Ebisui, Etsuko

AU - Nakamura, Kyoko

AU - Uchida, Kelko

AU - Kitaguchi, Tetsuya

AU - Takashi-Iwanaga, Hiromi

AU - Noda, Tetsuo

AU - Aruga, Jun

AU - Mikoshiba, Katsuhiko

PY - 2005/9/30

Y1 - 2005/9/30

N2 - Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3RB) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP 3R2 and IP3R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.

AB - Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3RB) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP 3R2 and IP3R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.

UR - http://www.scopus.com/inward/record.url?scp=25844462280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25844462280&partnerID=8YFLogxK

U2 - 10.1126/science.1114110

DO - 10.1126/science.1114110

M3 - Article

C2 - 16195467

AN - SCOPUS:25844462280

SN - 0036-8075

VL - 309

SP - 2232

EP - 2234

JO - Science

JF - Science

IS - 5744

ER -

Cell signaling: IP₃ receptor types 2 and 3 mediates exocrine secretion underlying energy metabolism

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this