Cell uptake of albumin with synthetic glycolipid

Toshinori Sato; Hajime Miyaguchi; Yoshio Okahata

doi:10.2745/dds.10.199

Cell uptake of albumin with synthetic glycolipid

Toshinori Sato, Hajime Miyaguchi, Yoshio Okahata

Research output: Contribution to journal › Article › peer-review

Abstract

Internalization of albumin with synthetic glycolipid into blood cell was investigated by flow cytemeter. 1,5-Dioctyl-N-glucono-L-glutamate (2C₈-glc) and dodecylmaltoside (DDM) enhanced the uptake of albumin into monocytes, but not into neutrophiles and granulocytes. Cationic lipids and anionic lipids showed no enhancment of cell uptake of albumin. Hemolysis was occured in the presence of DDM, but not in the presence of 2C₈-glc. The present study suggest that synthetic glycolipid 2C₈-glc is expected as a candidate for the delivery of proteins into blood monocytes.

Original language	English
Pages (from-to)	199-200
Number of pages	2
Journal	Drug Delivery System
Volume	10
Issue number	3
DOIs	https://doi.org/10.2745/dds.10.199
Publication status	Published - 1995
Externally published	Yes

Keywords

albumin
cell uptake
glycolipid

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.2745/dds.10.199

Cite this

@article{f6d2f93384f04ff3a7f7b8e9f41223a0,

title = "Cell uptake of albumin with synthetic glycolipid",

abstract = "Internalization of albumin with synthetic glycolipid into blood cell was investigated by flow cytemeter. 1,5-Dioctyl-N-glucono-L-glutamate (2C8-glc) and dodecylmaltoside (DDM) enhanced the uptake of albumin into monocytes, but not into neutrophiles and granulocytes. Cationic lipids and anionic lipids showed no enhancment of cell uptake of albumin. Hemolysis was occured in the presence of DDM, but not in the presence of 2C8-glc. The present study suggest that synthetic glycolipid 2C8-glc is expected as a candidate for the delivery of proteins into blood monocytes.",

keywords = "albumin, cell uptake, glycolipid",

author = "Toshinori Sato and Hajime Miyaguchi and Yoshio Okahata",

year = "1995",

doi = "10.2745/dds.10.199",

language = "English",

volume = "10",

pages = "199--200",

journal = "Drug Delivery System",

issn = "0913-5006",

publisher = "Japan Society of Drug Delivery System",

number = "3",

}

TY - JOUR

T1 - Cell uptake of albumin with synthetic glycolipid

AU - Sato, Toshinori

AU - Miyaguchi, Hajime

AU - Okahata, Yoshio

PY - 1995

Y1 - 1995

N2 - Internalization of albumin with synthetic glycolipid into blood cell was investigated by flow cytemeter. 1,5-Dioctyl-N-glucono-L-glutamate (2C8-glc) and dodecylmaltoside (DDM) enhanced the uptake of albumin into monocytes, but not into neutrophiles and granulocytes. Cationic lipids and anionic lipids showed no enhancment of cell uptake of albumin. Hemolysis was occured in the presence of DDM, but not in the presence of 2C8-glc. The present study suggest that synthetic glycolipid 2C8-glc is expected as a candidate for the delivery of proteins into blood monocytes.

AB - Internalization of albumin with synthetic glycolipid into blood cell was investigated by flow cytemeter. 1,5-Dioctyl-N-glucono-L-glutamate (2C8-glc) and dodecylmaltoside (DDM) enhanced the uptake of albumin into monocytes, but not into neutrophiles and granulocytes. Cationic lipids and anionic lipids showed no enhancment of cell uptake of albumin. Hemolysis was occured in the presence of DDM, but not in the presence of 2C8-glc. The present study suggest that synthetic glycolipid 2C8-glc is expected as a candidate for the delivery of proteins into blood monocytes.

KW - albumin

KW - cell uptake

KW - glycolipid

UR - http://www.scopus.com/inward/record.url?scp=85024295984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024295984&partnerID=8YFLogxK

U2 - 10.2745/dds.10.199

DO - 10.2745/dds.10.199

M3 - Article

AN - SCOPUS:85024295984

SN - 0913-5006

VL - 10

SP - 199

EP - 200

JO - Drug Delivery System

JF - Drug Delivery System

IS - 3

ER -

Cell uptake of albumin with synthetic glycolipid

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this