Cellular and molecular mechanisms of neuronal migration in neocortical development

Takao Honda, Hidenori Tabata, Kazunori Nakajima

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


The complicated mammalian brain structure arises from accurate movements of neurons from their birthplace to their final locations. Detailed observation of this migration process by various methods revealed that neuronal migration is highly motile and that there are different modes of migration. Moreover, mouse mutants or human disorders that disrupt normal migration have provided significant insights into molecular pathways that control the neuronal migration. Although our knowledge is still fragmentary, it is becoming clear that various molecules are participating in this process. In this review, we outline about the cellular and molecular mechanisms of neuronal migration in the cerebral cortex.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalSeminars in Cell and Developmental Biology
Issue number3
Publication statusPublished - 2003 Jun


  • Locomotion
  • Neuronal migration
  • Reeler
  • Reelin
  • Somal translocation

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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