Central action of atrial natriuretic polypeptide on blood pressure in conscious rats

Hiroshi Itoh, Kazuwa Nakao, Narito Morii, Takayuki Yamada, Shozo Shiono, Makoto Sakamoto, Akira Sugawara, Yoshihiko Saito, Goro Katsuura, Teruo Shiomu, Masami Eigyo, Akira Matsushita, Hiroo Imura

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats. The intracer-ebroventricular injection of α-human atrial natriuretic polypeptide did not promote any significant change in basal blood pressure, whereas it attenuated central angiotensin II-induced pressor response in a dose-dependent manner. The plasma atrial natriuretic polypeptide level did not change after the central administration of α-human atrial natriuretic polypeptide. These data implicate atrial natriuretic polypeptide as a factor in blood pressure regulation in the central nervous system.

Original languageEnglish
Pages (from-to)745-749
Number of pages5
JournalBrain Research Bulletin
Issue number5
Publication statusPublished - 1986 May
Externally publishedYes


  • Angiotensin II
  • Atrial natriuretic polypeptide
  • Blood pressure
  • Water and electrolyte balance

ASJC Scopus subject areas

  • Neuroscience(all)


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