Central action of atrial natriuretic polypeptide on blood pressure in conscious rats

Hiroshi Itoh; Kazuwa Nakao; Narito Morii; Takayuki Yamada; Shozo Shiono; Makoto Sakamoto; Akira Sugawara; Yoshihiko Saito; Goro Katsuura; Teruo Shiomu; Masami Eigyo; Akira Matsushita; Hiroo Imura

doi:10.1016/0361-9230(86)90147-4

Central action of atrial natriuretic polypeptide on blood pressure in conscious rats

Hiroshi Itoh, Kazuwa Nakao, Narito Morii, Takayuki Yamada, Shozo Shiono, Makoto Sakamoto, Akira Sugawara, Yoshihiko Saito, Goro Katsuura, Teruo Shiomu, Masami Eigyo, Akira Matsushita, Hiroo Imura

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats. The intracer-ebroventricular injection of α-human atrial natriuretic polypeptide did not promote any significant change in basal blood pressure, whereas it attenuated central angiotensin II-induced pressor response in a dose-dependent manner. The plasma atrial natriuretic polypeptide level did not change after the central administration of α-human atrial natriuretic polypeptide. These data implicate atrial natriuretic polypeptide as a factor in blood pressure regulation in the central nervous system.

Original language	English
Pages (from-to)	745-749
Number of pages	5
Journal	Brain Research Bulletin
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/0361-9230(86)90147-4
Publication status	Published - 1986 May
Externally published	Yes

Keywords

Angiotensin II
Atrial natriuretic polypeptide
Blood pressure
Water and electrolyte balance

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0361-9230(86)90147-4

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title = "Central action of atrial natriuretic polypeptide on blood pressure in conscious rats",

abstract = "The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats. The intracer-ebroventricular injection of α-human atrial natriuretic polypeptide did not promote any significant change in basal blood pressure, whereas it attenuated central angiotensin II-induced pressor response in a dose-dependent manner. The plasma atrial natriuretic polypeptide level did not change after the central administration of α-human atrial natriuretic polypeptide. These data implicate atrial natriuretic polypeptide as a factor in blood pressure regulation in the central nervous system.",

keywords = "Angiotensin II, Atrial natriuretic polypeptide, Blood pressure, Water and electrolyte balance",

author = "Hiroshi Itoh and Kazuwa Nakao and Narito Morii and Takayuki Yamada and Shozo Shiono and Makoto Sakamoto and Akira Sugawara and Yoshihiko Saito and Goro Katsuura and Teruo Shiomu and Masami Eigyo and Akira Matsushita and Hiroo Imura",

note = "Funding Information: We thank Mrs Hnoho Tabata and MIS\ Kazuko Horn for the 5ecretanal assistance This work was supported m part by research grants from the Japanese Ministry of Educatton. Sctence and Culture, the Japanese Mmtstry of Health and Welfare “Dtsorders of Adrenal Hormone” Research Committee. Japan. 1985. Japan Tabacco Inc and Yamanoucht Foundation for Research on Metabolic Disorders, by a research grant for cardtovascular diseases (60A-3) from the Japanese Mtnrstry of Health and Welfare and by Japan Heart Foundation Research Grant for 1985",

year = "1986",

month = may,

doi = "10.1016/0361-9230(86)90147-4",

language = "English",

volume = "16",

pages = "745--749",

journal = "Brain Research Bulletin",

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number = "5",

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T1 - Central action of atrial natriuretic polypeptide on blood pressure in conscious rats

AU - Itoh, Hiroshi

AU - Nakao, Kazuwa

AU - Morii, Narito

AU - Yamada, Takayuki

AU - Shiono, Shozo

AU - Sakamoto, Makoto

AU - Sugawara, Akira

AU - Saito, Yoshihiko

AU - Katsuura, Goro

AU - Shiomu, Teruo

AU - Eigyo, Masami

AU - Matsushita, Akira

AU - Imura, Hiroo

N1 - Funding Information: We thank Mrs Hnoho Tabata and MIS\ Kazuko Horn for the 5ecretanal assistance This work was supported m part by research grants from the Japanese Ministry of Educatton. Sctence and Culture, the Japanese Mmtstry of Health and Welfare “Dtsorders of Adrenal Hormone” Research Committee. Japan. 1985. Japan Tabacco Inc and Yamanoucht Foundation for Research on Metabolic Disorders, by a research grant for cardtovascular diseases (60A-3) from the Japanese Mtnrstry of Health and Welfare and by Japan Heart Foundation Research Grant for 1985

PY - 1986/5

Y1 - 1986/5

N2 - The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats. The intracer-ebroventricular injection of α-human atrial natriuretic polypeptide did not promote any significant change in basal blood pressure, whereas it attenuated central angiotensin II-induced pressor response in a dose-dependent manner. The plasma atrial natriuretic polypeptide level did not change after the central administration of α-human atrial natriuretic polypeptide. These data implicate atrial natriuretic polypeptide as a factor in blood pressure regulation in the central nervous system.

AB - The effect of intracerebroventricular administration of atrial natriuretic polypeptide on blood pressure was studied in conscious, unrestrained rats. The intracer-ebroventricular injection of α-human atrial natriuretic polypeptide did not promote any significant change in basal blood pressure, whereas it attenuated central angiotensin II-induced pressor response in a dose-dependent manner. The plasma atrial natriuretic polypeptide level did not change after the central administration of α-human atrial natriuretic polypeptide. These data implicate atrial natriuretic polypeptide as a factor in blood pressure regulation in the central nervous system.

KW - Angiotensin II

KW - Atrial natriuretic polypeptide

KW - Blood pressure

KW - Water and electrolyte balance

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SN - 0361-9230

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EP - 749

JO - Brain Research Bulletin

JF - Brain Research Bulletin

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ER -

Central action of atrial natriuretic polypeptide on blood pressure in conscious rats

Abstract

Keywords

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