Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats

Gotaro Shirakami, Hiroshi Itoh, Shin ichi Suga, Yasato Komatsu, Norio Hama, Kenjiro Mori, Kazuwa Nakao

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


The effect of intracerebroventricular injection of C-type natriuretic peptide (CNP) on arginine vasopressin (AVP) secretion was studied in conscious rats, and was compared to that of atrial natriuretic peptide (ANP). The AVP secretion induced by central injection of 0.1 nmol angiotensin II was significantly suppressed by the pretreatment with 1 nmol CNP. ANP at a dose of 0.1 nmol elicited almost equivalent suppressive action to 1 nmol CNP. Considering that CNP is a specific ligand for ANP-B receptor, while ANP is that for ANP-A receptor, the result demonstrates that CNP possesses the similar central action to ANP, and suggests that the distribution of ANP-A and ANP-B receptors and/or their affinity towards each natriuretic peptide are different in the central nervous system.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - 1993 Sept 3
Externally publishedYes


  • Angiotensin II
  • Arginine vasopressin
  • Atrial natriuretic peptide
  • C-Type natriuretic peptide
  • Natriuretic peptide receptor

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats'. Together they form a unique fingerprint.

Cite this